Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.
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A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambdaA ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocationThe PI3K/AKT Pathway and Renal Cell CarcinomaInsulin receptor signaling in normal and insulin-resistant statesInsulin resistance in clinical and experimental alcoholic liver diseaseTherapeutic targets of brain insulin resistance in sporadic Alzheimer's diseaseDefect of insulin signal in peripheral tissues: Important role of ceramideDirect binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cellsBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseThe effects of obesity on skeletal muscle regenerationThe PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cellsRegulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylationProtein kinase C isoforms: Multi-functional regulators of cell life and deathMechanisms for insulin resistance: common threads and missing linksMembrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.Role of ceramide in diabetes mellitus: evidence and mechanisms.Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivityPlasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling.Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insightOxidative stress, nitric oxide, and diabetes.Adiponectin signaling in the liverFatty acid synthase as a novel target for meningioma therapy.Reducing plasma membrane sphingomyelin increases insulin sensitivity.Metabolic syndrome as a risk factor for neurological disorders.Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseasesCeramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesisTargeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis.Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.Cancer treatment strategies targeting sphingolipid metabolism.Carnitine Palmitoyltransferase 1b Deficient Mice Develop Severe Insulin Resistance After Prolonged High Fat Diet Feeding.Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.Metabolic syndrome, aging and involvement of oxidative stressPI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains.Ceramides as modulators of cellular and whole-body metabolismCombinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane.Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase.The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.
P2860
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P2860
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Ceramide disables 3-phosphoino ...... a PKCzeta-dependent mechanism.
@en
Ceramide disables 3-phosphoino ...... ogy domain of protein kinase B
@nl
type
label
Ceramide disables 3-phosphoino ...... a PKCzeta-dependent mechanism.
@en
Ceramide disables 3-phosphoino ...... ogy domain of protein kinase B
@nl
prefLabel
Ceramide disables 3-phosphoino ...... a PKCzeta-dependent mechanism.
@en
Ceramide disables 3-phosphoino ...... ogy domain of protein kinase B
@nl
P2093
P2860
P1476
Ceramide disables 3-phosphoino ...... a PKCzeta-dependent mechanism
@en
P2093
Darren J Powell
Gursant Kular
Harinder S Hundal
P2860
P304
P356
10.1128/MCB.23.21.7794-7808.2003
P407
P50
P577
2003-11-01T00:00:00Z