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A paracrine requirement for hedgehog signalling in cancer.

A paracrine requirement for hedgehog signalling in cancer.

http://www.wikidata.org/entity/Q39946287

about

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Deciphering the role of hedgehog signaling in pancreatic cancer Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review Molecular therapeutics in pancreas cancer Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling Hedgehog Signaling in the Maintenance of Cancer Stem Cells Hedgehog Signaling in Malignant Pleural Mesothelioma BMPs and their clinical potentials Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy Desmoplasia and chemoresistance in pancreatic cancer Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms Hedgehog signaling pathway in ovarian cancer Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench Genetically engineered mouse models of pancreatic adenocarcinoma Human correlates of provocative questions in pancreatic pathology Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site Carcinoma-associated fibroblasts: orchestrating the composition of malignancy Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells Hedgehog signaling and the Gli code in stem cells, cancer, and metastases Targeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: molecular basis for therapeutic implications Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

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P2860

A paracrine requirement for hedgehog signalling in cancer.

http://www.wikidata.org/entity/Q39946287

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

A paracrine requirement for hedgehog signalling in cancer.

@en

A paracrine requirement for hedgehog signalling in cancer.

@nl

type

label

A paracrine requirement for hedgehog signalling in cancer.

@en

A paracrine requirement for hedgehog signalling in cancer.

@nl

prefLabel

A paracrine requirement for hedgehog signalling in cancer.

@en

A paracrine requirement for hedgehog signalling in cancer.

@nl

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A paracrine requirement for hedgehog signalling in cancer.

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Christina P Ahn

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Dara Kallop

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Derek Marshall

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Frederic J de Sauvage

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Hua Tian

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James C Marsters

http://www.w3.org/2001/XMLSchema#string

Karen Kotkow

http://www.w3.org/2001/XMLSchema#string

Lee L Rubin

http://www.w3.org/2001/XMLSchema#string

Ling Fu

http://www.w3.org/2001/XMLSchema#string

Michelle Nannini-Pepe

http://www.w3.org/2001/XMLSchema#string

P2860

Stromal fibroblasts in cancer: a novel tumor-promoting cell type.

P2888

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406-410

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scholarly article

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10.1038/NATURE07275

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7211

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455

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Stephen E. Gould

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2008-08-27T00:00:00Z

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