Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
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NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell linesATP-dependent human RISC assembly pathwaysThe promises and pitfalls of RNA-interference-based therapeuticssiRNA and RNAi optimizationThe functional role of microRNA in acute lymphoblastic leukemia: relevance for diagnosis, differential diagnosis, prognosis, and therapysiRNA delivery to the lung: what's new?Abasic pivot substitution harnesses target specificity of RNA interferencePreclinical and clinical development of siRNA-based therapeuticsDownregulation of KIF23 suppresses glioma proliferationProgress toward in vivo use of siRNAs-IITenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in miceSilencing disease genes in the laboratory and the clinicSequence determinants of innate immune activation by short interfering RNAs.Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs.Recognition of siRNA asymmetry by TAR RNA binding protein.Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencingEffect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters.Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.Inhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy.Designing highly active siRNAs for therapeutic applications.Mammalian Argonaute-DNA binding?RNA interference for improving the outcome of islet transplantation.Vigilance and validation: Keys to success in RNAi screening.Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering.Lack of correlation between predicted and actual off-target effects of short-interfering RNAs targeting the human papillomavirus type 16 E7 oncogene.RORC2 gene silencing in human Th17 cells by siRNA: design and evaluation of highly efficient siRNA.A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicitySilencing sexually transmitted infections: topical siRNA-based interventions for the prevention of HIV and HSVChemical modification of siRNA.Novel RNA-based strategies for therapeutic gene silencing.Engineering RNA for targeted siRNA delivery and medical application.Leveraging therapeutic potential of multi-targeted siRNA inhibitors.Unlocked nucleic acid--an RNA modification with broad potential.Research progress on siRNA delivery with nonviral carriers.Countering hepatitis B virus infection using RNAi: how far are we from the clinic?Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.RNA interference trigger variants: getting the most out of RNA for RNA interference-based therapeuticsTherapeutic siRNA: principles, challenges, and strategies.Delivery of RNAi therapeutics: work in progress.
P2860
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P2860
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Functional dissection of siRNA ...... tly reduced off-target effect.
@en
type
label
Functional dissection of siRNA ...... tly reduced off-target effect.
@en
prefLabel
Functional dissection of siRNA ...... tly reduced off-target effect.
@en
P2093
P2860
P356
P1476
Functional dissection of siRNA ...... ntly reduced off-target effect
@en
P2093
Fumitaka Takahashi
Kaoru Saigo
Kenji Nishi
Kenji Yamato
Kumiko Ui-Tei
Shuhei Zenno
P2860
P304
P356
10.1093/NAR/GKN042
P50
P577
2008-02-11T00:00:00Z