mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
about
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinHuman immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapyMdm2 targets the p53 transcription cofactor JMY for degradationHIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic functionThe Mdm2 oncoprotein interacts with the cell fate regulator NumbAdenovirus E1B 55K represses p53 activation in vitro.Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationMDM2 suppresses p73 function without promoting p73 degradationPw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosisNucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53Genetic susceptibility to lung cancer--light at the end of the tunnel?Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic geneBID regulation by p53 contributes to chemosensitivityThe MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoterA unique glucose-dependent apoptotic pathway induced by c-MycA novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2A genetic approach to mapping the p53 binding site in the MDM2 proteinGene therapy of lung cancer.C-terminal ubiquitination of p53 contributes to nuclear exportMdm2: the ups and downs.Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.Increased sinusoidal flow is not the primary stimulus to liver regeneration.Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release.Regulation of Mdm2-directed degradation by the C terminus of p53.Identification of positive and negative regulatory regions involved in regulating expression of the human cytomegalovirus UL94 late promoter: role of IE2-86 and cellular p53 in mediating negative regulatory function.mdm2: a bridge over the two tumour suppressors, p53 and Rb.Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.DNA-binding and transactivation activities are essential for TAp63 protein degradation.Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesisc-Myc overexpression uncouples DNA replication from mitosis.Tumor suppressor p53 is required to modulate BRCA1 expression.Negative regulation of tumor suppressor p53 by microRNA miR-504A plausible model for the digital response of p53 to DNA damage.Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint.Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.
P2860
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P2860
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
@en
type
label
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
@en
prefLabel
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
@en
P2093
P2860
P356
P1476
mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
@en
P2093
P2860
P304
P356
10.1128/MCB.16.5.2445
P407
P577
1996-05-01T00:00:00Z