Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
about
Macrocyclic histone deacetylase inhibitorsTiny Microbes with a Big Impact: The Role of Cyanobacteria and Their Metabolites in Shaping Our FutureTargeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidatesMarine cyanobacteria compounds with anticancer properties: a review on the implication of apoptosisStructural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone DeacetylasesLargazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited successConstraining cyclic peptides to mimic protein structure motifs.Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance.Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena.Largazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells.Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.Halogenated compounds from marine algae.Potent and orally efficacious bisthiazole-based histone deacetylase inhibitorsSynthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole.Marine natural products: a new wave of drugs?Evaluation of class I HDAC isoform selectivity of largazole analoguesModulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug PropertiesEnantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase.Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.Synthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsSeaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathwayBiologically active secondary metabolites from marine cyanobacteriaAnticancer drugs from marine flora: an overview.Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.Interpreting clinical assays for histone deacetylase inhibitors.Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.In Vitro and In Vivo Osteogenic Activity of Largazole.Biological targets and mechanisms of action of natural products from marine cyanobacteria.Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostereCyclic depsipeptides, grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya cyanobacterium.Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor.Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.
P2860
Q24629065-9E8BBFC8-2374-431F-8FD7-898E47B1CA08Q26747668-36082362-DA04-40FC-BC69-598D025E3E13Q26784489-B1A16E74-38D5-40FA-B11B-64AAB1F32493Q27021618-5950E202-4E38-413C-B76A-3166675ECF98Q27671010-93E2E863-185C-43F6-9940-DCB92E37834FQ28258201-0A7E8DAB-1C0B-48F1-9B86-039B8B5593F8Q28822336-11F32B2F-A1DE-46DF-9F74-132A463E2CA9Q30367509-365ACC62-256E-4E0E-9FB8-678B5DBA3586Q30479486-0ADC9E61-A62F-4704-A89C-A7F7AFC7622BQ30990961-135AB505-9E0D-4190-8AC3-25328E5AD505Q33496543-4C7EED34-8C95-464F-805F-C6434C932F07Q33605663-97CC52B8-C500-4B1C-8DA6-4113F06986C2Q33636007-E0BA524A-5C0C-4D20-9FEA-6904B12282F8Q33636013-E78C93BC-4BC4-4469-9FAC-0B21CC4E4F5BQ33719124-A10CA59A-AE71-492C-AC54-2CB44BCF5244Q33768549-89D0C7F5-98FC-4A05-A658-8DC4FF069FFFQ33893992-52C6E246-C7D2-4A39-8A1D-EECD643A08B9Q34007283-14D90775-A6E0-443B-928A-169555455A8BQ34054267-927761C8-94EE-4445-B56A-2D8FA3625FEFQ34063722-82FAF2F0-7694-4340-B692-79D066668874Q34156653-AA0A4BD6-69BB-4575-AD77-F6C9C0B57DD4Q34257533-DC6AEA32-E4F4-4BEB-AEA8-69D24F91AB75Q34302247-A9E79D19-86EF-4CE8-AC5D-5DF1BBE673CBQ34537322-ADBA28CC-D69D-43BD-9BFF-7E31DA4C0724Q34554921-DC71FEA9-0ECE-46DD-B2CE-A9849E2F45D0Q34726833-9235840F-D397-4A7F-8895-F148D6EDA0A3Q34958178-CCB77205-12DB-4A01-B771-5A325A75A342Q35003657-EC469EE2-CC6C-495C-96F0-3A802BF917D6Q35012103-052AE93B-F4C0-4138-8F4E-4B01CA5B7825Q35030533-3EE1F3B2-C7AF-4601-9C6F-5E41509B0D2FQ35130835-299B1BB6-E5D8-47D1-868C-0EEF37FB99F4Q35202369-5FE8534B-0178-4B2A-8E2C-D294AF2F3EBCQ35206631-D13B06CB-A311-4338-ACB5-C1592F258A04Q35214924-E2E48FD6-6AD8-4881-9B38-0BFACFDF593CQ35215703-088834D8-635B-454F-9042-895FDE5C677DQ35243482-15CCEBE2-8AA2-4945-9625-B650E5B68E0BQ35597103-9403EC0C-8F7C-401E-B6AF-ECD9C354F1B2Q35656966-823F0989-464D-4148-B1BE-C20E25BBB685Q35700138-50FF0920-6E04-4F1A-81D7-4ECF18C4599FQ35920661-85F38E06-50F1-40D8-BCF8-9B80564FAA12
P2860
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Structure and activity of larg ...... ne cyanobacterium Symploca sp.
@en
type
label
Structure and activity of larg ...... ne cyanobacterium Symploca sp.
@en
prefLabel
Structure and activity of larg ...... ne cyanobacterium Symploca sp.
@en
P2093
P356
P1476
Structure and activity of larg ...... ne cyanobacterium Symploca sp.
@en
P2093
Hendrik Luesch
Kanchan Taori
Valerie J Paul
P304
P356
10.1021/JA7110064
P407
P577
2008-01-19T00:00:00Z