The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
about
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailProline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentExosomes: Implications in HIV-1 PathogenesisRefined solution structure and backbone dynamics of HIV-1 Nef.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathwayHuman immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinInteraction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellThe two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseInduction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetateAn internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surfaceInfectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinaseThe human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.HIV-1 Nef: at the crossroadsA basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.Mechanisms of HIV-1 Nef function and intracellular signaling.Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.Viral factors in non-progression.Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes.Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice.Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.Physiologically-based modeling to predict the clinical behavior of monoclonal antibodies directed against lymphocyte antigens.
P2860
Q24310700-8D5FE080-559E-467F-9842-90529BDB6DCCQ24313595-94856135-C92D-4648-A8FD-C5FD526F63F7Q24532862-08E038D8-88B5-452C-AC98-49177624C111Q24680648-0A49CF11-2F0C-4C03-B9EA-0947F27061A3Q26800051-6BC36D18-9395-42BC-B23C-28A96197CCA7Q30176531-BC1DA8A9-0B61-41CB-A781-11BCC7073E73Q30193319-59B63AA8-4F47-4BD2-ACDA-D430F4CA4B17Q33782459-B3F9B811-2C69-4FB0-95E3-E70E02281905Q33814659-5898CD98-323B-4CAC-8EB5-9673F8647E3EQ33850973-98AC5EFD-2239-493C-96AF-8D22E7AC5517Q34283497-93AA0088-0AC5-442B-B06D-36FE5FA5C298Q34572074-E43DD67D-BC12-454A-81FB-3651987A73DBQ35785393-D7B111A5-83E3-4554-B274-25A556E18E9AQ35840793-2C9D5157-F73E-4631-96EF-C3D9ECE466ACQ35854362-FE690395-2D5F-41CB-BC10-70C467B7818EQ35856359-069B903E-8E41-4400-879D-773806E289CBQ35872157-48A507C4-B11D-4265-914F-66D26FE6C5B9Q35876343-543EE013-E298-4E06-A36C-27F910847C13Q35879946-EEF1E7C2-7884-4042-AA25-3D27E369130DQ36236526-125DE123-1165-410D-B074-10F8163DB66EQ36549003-92998522-8B85-4446-ABA1-033161CCB6CFQ36669879-66DF1752-876D-4CEB-B7B6-C3DA66E41EC9Q36926697-55606BDA-0162-4994-A25E-072DEC318BE0Q37110624-97AA1FE5-6558-4E88-AE1D-CC76F7630501Q37183848-F4B5B765-584E-436E-B91D-152DA1F6673BQ37232786-02CFCB7A-426C-4DB7-9FBE-B0C440A09FC6Q37412098-FC9EBDEB-F6B0-41D6-BEF2-AF98CAF90D7BQ37596471-04A28205-C76F-4976-9990-FDA90EB4AB64Q38657287-135DADA7-EBB3-40DC-9BCA-4F566FED86BAQ39606016-4EF4C719-6FA2-439A-9B22-4F094894C421Q39868503-BAFE3926-D826-4EA9-B46F-B48636708E92Q39868549-DFAFDE7F-C404-4554-822C-76D1BA39A446Q39872268-502684EF-BBBD-44A2-8B19-EEF7087F8223Q44779448-258CAAB9-3C5E-420A-AD5E-0983C748507A
P2860
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The cytoplasmic domain of CD4 ...... nodeficiency virus type 1 Nef.
@en
type
label
The cytoplasmic domain of CD4 ...... nodeficiency virus type 1 Nef.
@en
prefLabel
The cytoplasmic domain of CD4 ...... nodeficiency virus type 1 Nef.
@en
P2093
P2860
P1433
P1476
The cytoplasmic domain of CD4 ...... nodeficiency virus type 1 Nef.
@en
P2093
J V Garcia
N R Landau
S J Anderson
P2860
P304
P407
P577
1994-05-01T00:00:00Z