Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. - Wikidata - wikimedia - TriplyDB

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.

http://www.wikidata.org/entity/Q40051060

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Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib Raf family kinases: old dogs have learned new tricks Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades Raf-1: a novel cardiac troponin T kinase Scaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and Disease What links BRAF to the heart function? New insights from the cardiotoxicity of BRAF inhibitors in cancer treatment Signaling effectors underlying pathologic growth and remodeling of the heart The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock The case for inhibiting p38 mitogen-activated protein kinase in heart failure Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model Regulation and role of Raf-1/B-Raf heterodimerization.Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription Cancer therapy-induced cardiotoxicity: basic mechanisms and potential cardioprotective therapies.RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.Sorafenib-Associated Heart Failure Complicated by Cardiogenic Shock after Treatment of Advanced Stage Hepatocellular Carcinoma: A Clinical Case Discussion Sorafenib cardiotoxicity increases mortality after myocardial infarction.Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.Cardio-Oncology: Cancer Therapy-related Cardiovascular Complications in a Molecular Targeted Era: New Concepts and Perspectives.ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning.Calpain protects the heart from hemodynamic stress.Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectives Essential role of B-Raf in ERK activation during extraembryonic development Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.Redox signaling and cardiac sarcomeres Anthrax lethal and edema toxins produce different patterns of cardiovascular and renal dysfunction and synergistically decrease survival in canines Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury Cardiovascular safety of VEGF-targeting therapies: current evidence and handling strategies ERK signaling, but not c-Raf, is required for gonadotropin-releasing hormone (GnRH)-induced regulation of Nur77 in pituitary gonadotropes Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.Raf kinases: function, regulation and role in human cancer.Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants Protein kinases of the Hippo pathway: regulation and substrates.Novel roles of PAK1 in the heart.Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway.

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P2860

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.

http://www.wikidata.org/entity/Q40051060

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年论文

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Cardiac-specific disruption of ...... iac dysfunction and apoptosis.

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Cardiac-specific disruption of ...... iac dysfunction and apoptosis.

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Cardiac-specific disruption of ...... iac dysfunction and apoptosis.

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Journal of Clinical Investigation

P1476

Cardiac-specific disruption of ...... iac dysfunction and apoptosis.

@en

P2093

Atsuko Nakai

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Atsushi Matsuzawa

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Chiharu Sadamitsu

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Ikuko Tsujimoto

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Jun-ichi Miyazaki

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Kazuhiko Nishida

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Kazunori Kashiwase

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Kenneth R Chien

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Kinya Otsu

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Masatsugu Hori

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P2860

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

Phosphorylation and regulation of Raf by Akt (protein kinase B)

MEK kinase activity is not necessary for Raf-1 function.

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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937-943

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10.1172/JCI20317

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7

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114

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Hidenori Ichijo

Manuela Baccarini

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2004-10-01T00:00:00Z

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15467832

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518660

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