Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
about
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2AProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingCarboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunitsDifferential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progressionShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexesCatalytically inactive protein phosphatase 2A can bind to polyomavirus middle tumor antigen and support complex formation with pp60(c-src).A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: requirement for insulin- and lysophosphatidic acid-mediated signal transduction.Natural biology of polyomavirus middle T antigen.Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigenEnhancer-mediated role for polyomavirus middle T/small T in DNA replication.Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A.Human cytomegalovirus carries serine/threonine protein phosphatases PP1 and a host-cell derived PP2ARetroviral cyclin enhances cyclin-dependent kinase-8 activity.Circumventing cellular control of PP2A by methylation promotes transformation in an Akt-dependent mannerEvidence that the middle T antigen of polyomavirus interacts with the membrane skeletonDeficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport.Novel monoclonal antibodies that differentiate between the binding of pp60c-src or protein phosphatase 2A by polyomavirus middle T antigen.pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.
P2860
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P2860
Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Characterization of the intera ...... h type 2A protein phosphatase.
@en
type
label
Characterization of the intera ...... h type 2A protein phosphatase.
@en
prefLabel
Characterization of the intera ...... h type 2A protein phosphatase.
@en
P2093
P2860
P1433
P1476
Characterization of the intera ...... h type 2A protein phosphatase.
@en
P2093
Cartwright AJ
Courtneidge SA
P2860
P304
P407
P577
1992-03-01T00:00:00Z