27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
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Lipoprotein(a), hormone replacement therapy, and risk of future cardiovascular eventsThe Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infectionCholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancerCurrent trends in oxysterol researchOverlapping nongenomic and genomic actions of thyroid hormone and steroidsDifferential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasionCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant TherapyOxpholipin 11D: an anti-inflammatory peptide that binds cholesterol and oxidized phospholipidsNuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.A theory of eu-estrogenemia: a unifying concept.CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functionsMinireview: Estrogen receptor-beta: mechanistic insights from recent studies.Oxysterols and their cellular effectors.The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells.Importance of estrogen metabolitesDifferential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytesThe cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.Gender disparity of hepatic lipid homoeostasis regulated by the circadian clockThe endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.Obesity, cholesterol metabolism, and breast cancer pathogenesisFrom empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs).Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology.A screening cascade to identify ERβ ligands.Minireview: Extranuclear steroid receptors: roles in modulation of cell functions.Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunityImpact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease.Cholesterol and breast cancer pathophysiology.27-Hydroxycholesterol: the first identified endogenous SERMThe interaction between metabolism, cancer and cardiovascular disease, connected by 27-hydroxycholesterol.The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer.A tricistronic human adrenodoxin reductase-adrenodoxin-cytochrome P450 27A1 vector system for substrate hydroxylation in Escherichia coliAndrogens and estrogens in benign prostatic hyperplasia: past, present and future.Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery.Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function.The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
P2860
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P2860
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
27-Hydroxycholesterol is an en ...... ovascular effects of estrogen.
@en
type
label
27-Hydroxycholesterol is an en ...... ovascular effects of estrogen.
@en
prefLabel
27-Hydroxycholesterol is an en ...... ovascular effects of estrogen.
@en
P2093
P356
P1433
P1476
27-Hydroxycholesterol is an en ...... ovascular effects of estrogen.
@en
P2093
Andrew K Gormley
David J Mangelsdorf
Hideharu Domoto
Ivan S Yuhanna
Michihisa Umetani
Norman B Javitt
Philip W Shaul
P2888
P304
P356
10.1038/NM1641
P407
P577
2007-09-16T00:00:00Z
P5875
P6179
1040545871