Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation. - Wikidata - wikimedia - TriplyDB

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

http://www.wikidata.org/entity/Q40173384

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An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual Defects in Germinal Center Selection in SLE The clinical relevance of animal models in Sjögren's syndrome: the interferon signature from mouse to man B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation Altered B cell signalling in autoimmunity.B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.TLR7 influences germinal center selection in murine SLE.Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice.New insights into B cell biology in systemic lupus erythematosus and Sjögren's syndrome Female Bias in Systemic Lupus Erythematosus is Associated with the Differential Expression of X-Linked Toll-Like Receptor 8 Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and autoimmunity.Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice.B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome.IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.The effect of BAFF inhibition on autoreactive B cell selection in murine SLE.Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus.Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics.TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells.Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus.Spontaneous germinal centers and autoimmunity.Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus.A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation.Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses.Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen.

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Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.

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Opposing impact of B cell-intr ...... ire and systemic inflammation.

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JIMMUNOL.1400098

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Journal of Immunology

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Opposing impact of B cell-intr ...... ire and systemic inflammation.

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Charles E Alpers

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David J Rawlings

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Denny Liggitt

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Kelly L Hudkins

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Marc A Schwartz

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Nikita S Kolhatkar

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Quan-Zhen Li

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Shaun W Jackson

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Socheath Khim

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P2860

Measurement of anti-DNA antibodies: a reappraisal using five different methods.

Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

Fifty years of anti-ds DNA antibodies: are we approaching journey's end?

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

BAFF and MyD88 signals promote a lupuslike disease independent of T cells.

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity.

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4525-4532

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scholarly article

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10.4049/JIMMUNOL.1400098

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10

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192

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Nicole E Scharping

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2014-04-07T00:00:00Z

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261445073

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24711620

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Toll-like receptor

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4041708

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