BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. - Wikidata - wikimedia - TriplyDB

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

http://www.wikidata.org/entity/Q40220439

about

P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases The selectivity of protein kinase inhibitors: a further update AKT/PKB signaling: navigating downstream Molecular Targeting of ERKs/RSK2 Signaling Axis in Cancer Prevention RSK isoforms in cancer cell invasion and metastasis Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.Dual kinase-bromodomain inhibitors for rationally designed polypharmacology p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer RSK3: A regulator of pathological cardiac remodeling Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2 DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases SH3P2 is a negative regulator of cell motility whose function is inhibited by ribosomal S6 kinase-mediated phosphorylation.Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2)Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH)The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication RSK2 Binding Models Delineate Key Features for Activity Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replication RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity 7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo.CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Ribosomal S6 kinase regulates ischemia-induced progenitor cell proliferation in the adult mouse hippocampus.Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia

P2860

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P2860

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.

http://www.wikidata.org/entity/Q40220439

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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BI-D1870 is a specific inhibit ...... isoforms in vitro and in vivo.

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BI-D1870 is a specific inhibit ...... isoforms in vitro and in vivo.

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BI-D1870 is a specific inhibit ...... isoforms in vitro and in vivo.

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Biochemical Journal

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BI-D1870 is a specific inhibit ...... isoforms in vitro and in vivo.

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P2093

Christopher Armstrong

http://www.w3.org/2001/XMLSchema#string

Felicity S Newell

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Gisela Schnapp

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Gopal P Sapkota

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Jennifer Bain

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Lorna Cummings

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Martin Steegmaier

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Matthias Grauert

http://www.w3.org/2001/XMLSchema#string

Matthias Hoffmann

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Morten Frodin

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P2860

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

The protein kinase complement of the human genome

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

The PI3K-PDK1 connection: more than just a road to PKB

The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

P304

29-38

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scholarly article

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10.1042/BJ20061088

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P433

1

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401

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2007-01-01T00:00:00Z

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6755758

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17040210

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1698666

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