Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.
about
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sitesMutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomasProtective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesisNovel multiplexed assay for identifying SH2 domain antagonists of STAT family proteinsIdentifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discoveryFunctional implication of BAFF synthesis and release in gangliosides-stimulated microgliaDysregulation of suppressor of cytokine signaling 3 in keratinocytes causes skin inflammation mediated by interleukin-20 receptor-related cytokinesMultifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner.Therapeutic modulators of STAT signalling for human diseasesKinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cellsThe role of the JAK2-STAT3 pathway in pro-inflammatory responses of EMF-stimulated N9 microglial cells.CNTF-evoked activation of JAK and ERK mediates the functional expression of T-type Ca2+ channels in chicken nodose neurons.HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humansPeripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130.High basal expression of interferon-stimulated genes in human bronchial epithelial (BEAS-2B) cells contributes to influenza A virus resistanceThe CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro.Leukemia inhibitory factor regulates trafficking of T-type Ca2+ channels.Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.Polycystin-1 regulates STAT activity by a dual mechanismGP130 activation induces myeloma and collaborates with MYC.Antitumorigenic potential of STAT3 alternative splicing modulationThe novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activityHepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.Protection of porcine endothelial cells against apoptosis with interleukin-4.Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.Bone marrow microenvironment and the identification of new targets for myeloma therapy.Identification of novel small molecules that inhibit STAT3-dependent transcription and function.Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells.JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in ratsEstablishing the role of tyrosine kinase 2 in cancer.An array of possibilities in cancer research using cytokine antibody arrays.
P2860
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P2860
Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Pyridone 6, a pan-Janus-activa ...... ion of multiple myeloma cells.
@en
type
label
Pyridone 6, a pan-Janus-activa ...... ion of multiple myeloma cells.
@en
prefLabel
Pyridone 6, a pan-Janus-activa ...... ion of multiple myeloma cells.
@en
P2093
P1433
P1476
Pyridone 6, a pan-Janus-activa ...... ion of multiple myeloma cells.
@en
P2093
Jacqueline Bromberg
Janeen Azare
Laura Pedranzini
Marjan Berishaj
Raymond Comenzo
Tobias Dechow
William Bornmann
P304
P356
10.1158/0008-5472.CAN-05-4280
P407
P577
2006-10-01T00:00:00Z