Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.
about
The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cellsAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseSoluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsGenetic heterogeneity in Alzheimer disease and implications for treatment strategiesTau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in MicePhenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsDexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcriptionFe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaksPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionGene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neuronsCo-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutantProteomic profiling of gamma-secretase substrates and mapping of substrate requirementsStructural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice.Regulation of amyloid precursor protein processing by the Beclin 1 complexbeta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortexWhat is the role of amyloid precursor protein dimerization?Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease.Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complexEpigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer diseaseThe roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease.Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine QuadruplexAmyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.X-linked mental retardation and epigenetics.Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional roleMetalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretaseA TAG on to the neurogenic functions of APP
P2860
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P2860
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Regulated intramembrane proteo ...... sion of putative target genes.
@en
type
label
Regulated intramembrane proteo ...... sion of putative target genes.
@en
prefLabel
Regulated intramembrane proteo ...... sion of putative target genes.
@en
P2093
P2860
P356
P1433
P1476
Regulated intramembrane proteo ...... sion of putative target genes.
@en
P2093
Alexandra Tolia
Carmen Derks
Katleen Craessaerts
Lutgarde Serneels
Mikhail A Filippov
Sébastien S Hébert
Ulrike Müller
P2860
P304
P356
10.1038/SJ.EMBOR.7400704
P577
2006-05-19T00:00:00Z