Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.
about
Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175HControl of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradationA novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics.Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.Ubiquitination and degradation of mutant p53.MDM2 chaperones the p53 tumor suppressor.The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members.Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.Does control of mutant p53 by Mdm2 complicate cancer therapy?Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif.ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.
P2860
Q24310790-37ACD6B5-2FE0-440C-9DC0-076D1FB59086Q33655851-1A71897C-B274-48D9-AF3A-49639DF3A359Q33695618-97CA0999-9708-4F90-82D3-FE175D4B9410Q34333807-325084FE-2847-41A6-A1DB-01F808BFC324Q36537788-0E242331-4FBC-4458-92CA-E98B078219DDQ38960209-E8A7FF78-4468-416B-933A-232C5867F901Q40073806-545303FB-D76A-43F6-A2BD-33517050D59CQ40082372-43B0FF55-E758-485E-8FD8-139ED94865AEQ40163084-8A17F548-E47B-4619-8890-C2A48B659A4FQ40842578-E78D5CB9-6DF0-48BA-BA33-EF16BF4805A4Q42035568-E1210CFA-9D06-4101-AEFD-4B3E021BD1DDQ42089987-1A71C6F7-E8B8-46D7-A8CD-32186C81B5B7Q43675801-B6AC11E1-DFA3-4A4C-9D3E-4EAB28A4EB54
P2860
Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Destabilizing missense mutatio ...... tination in vitro and in vivo.
@en
type
label
Destabilizing missense mutatio ...... tination in vitro and in vivo.
@en
prefLabel
Destabilizing missense mutatio ...... tination in vitro and in vivo.
@en
P2093
P2860
P356
P1433
P1476
Destabilizing missense mutatio ...... tination in vitro and in vivo.
@en
P2093
David Saliba
Harumi Shimizu
Lee Finlan
Maura Wallace
Patrick R R Langridge-Smith
Ted R Hupp
P2860
P304
P356
10.1042/BJ20051521
P407
P577
2006-07-01T00:00:00Z