Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. - Wikidata - wikimedia - TriplyDB

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

http://www.wikidata.org/entity/Q40299714

about

Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes Effect of endocrine disruptor pesticides: a review Hypospadias and residential proximity to pesticide applications Using nuclear receptor activity to stratify hepatocarcinogens Fate of organohalogens in US wastewater treatment plants and estimated chemical releases to soils nationwide from biosolids recycling.Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.Small-molecule modulators of the constitutive androstane receptor.RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Examination of the carboxylesterase phenotype in human liver A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Environmental toxins: alarming impacts of pesticides on male fertility.The novel antibacterial compound walrycin A induces human PXR transcriptional activity Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.Fipronil insecticide toxicology: oxidative stress and metabolism.Distribution of steroid- and dioxin-like activities between sediments, POCIS and SPMD in a French river subject to mixed pressures.Chemical and toxicological assessment of a full-scale biosolid compost.Affinity purification using recombinant PXR as a tool to characterize environmental ligands.Characterization of endocrine disruptors from a complex matrix using estrogen receptor affinity columns and high performance liquid chromatography-high resolution mass spectrometry.Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view.PXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids.Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors.Evaluation of an extraction method for a mixture of endocrine disrupters in sediment using chemical and in vitro biological analyses.Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro

P2860

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P2860

Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

http://www.wikidata.org/entity/Q40299714

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年论文

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2006年论文

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name

Identification of new human pr ...... a stable reporter cell system.

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Identification of new human pr ...... a stable reporter cell system.

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Toxicological Sciences

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Identification of new human pr ...... a stable reporter cell system

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Arnaud Pillon

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Claude Casellas

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Elena Gomez

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Fanja Rabenoelina

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Géraldine Lemaire

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Hélène Fenet

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Jean-Claude Nicolas

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Marie-Josèphe Duchesne

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Patrick Balaguer

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Wissem Mnif

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P2860

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Reporter cell lines to study the estrogenic effects of xenoestrogens

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.

A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects.

In vitro and in vivo drug interactions involving human CYP3A.

Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents

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2

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91

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Jean Marc Pascussi

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