Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.
about
Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytesEffect of endocrine disruptor pesticides: a reviewHypospadias and residential proximity to pesticide applicationsUsing nuclear receptor activity to stratify hepatocarcinogensFate of organohalogens in US wastewater treatment plants and estimated chemical releases to soils nationwide from biosolids recycling.Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.Small-molecule modulators of the constitutive androstane receptor.RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Examination of the carboxylesterase phenotype in human liverA concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Environmental toxins: alarming impacts of pesticides on male fertility.The novel antibacterial compound walrycin A induces human PXR transcriptional activityAnalysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.Fipronil insecticide toxicology: oxidative stress and metabolism.Distribution of steroid- and dioxin-like activities between sediments, POCIS and SPMD in a French river subject to mixed pressures.Chemical and toxicological assessment of a full-scale biosolid compost.Affinity purification using recombinant PXR as a tool to characterize environmental ligands.Characterization of endocrine disruptors from a complex matrix using estrogen receptor affinity columns and high performance liquid chromatography-high resolution mass spectrometry.Epigenetic impact of endocrine disrupting chemicals on lipid homeostasis and atherosclerosis: a pregnane X receptor-centric view.PXR mediated induction of CYP3A4, CYP1A2, and P-gp by Mitragyna speciosa and its alkaloids.Molecular interactions of dioxins and DLCs with the xenosensors (PXR and CAR): An in silico risk assessment approach.Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors.Evaluation of an extraction method for a mixture of endocrine disrupters in sediment using chemical and in vitro biological analyses.Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
P2860
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P2860
Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Identification of new human pr ...... a stable reporter cell system.
@en
type
label
Identification of new human pr ...... a stable reporter cell system.
@en
prefLabel
Identification of new human pr ...... a stable reporter cell system.
@en
P2093
P2860
P356
P1476
Identification of new human pr ...... a stable reporter cell system
@en
P2093
Arnaud Pillon
Claude Casellas
Elena Gomez
Fanja Rabenoelina
Géraldine Lemaire
Hélène Fenet
Jean-Claude Nicolas
Marie-Josèphe Duchesne
Patrick Balaguer
Wissem Mnif
P2860
P304
P356
10.1093/TOXSCI/KFJ173
P577
2006-03-24T00:00:00Z