MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
about
Membrane-bound mucins: the mechanistic basis for alterations in the growth and survival of cancer cellsMucins in cancer: function, prognosis and therapyCleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeastIntra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and MetastasisReview of hormone-based treatments in postmenopausal patients with advanced breast cancer focusing on aromatase inhibitors and fulvestrantCooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cellsIncreased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.Targeting the MUC1-C oncoprotein inhibits self-renewal capacity of breast cancer cells.Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alphaHuman endometrial DNA methylome is cycle-dependent and is associated with gene expression regulationMucin 1 C-terminal subunit oncoprotein is a target for small-molecule inhibitors.MUC1 regulates nuclear localization and function of the epidermal growth factor receptor.The cytoplasmic domain of MUC1 induces hyperplasia in the mammary gland and correlates with nuclear accumulation of β-catenin.Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) familyImpact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell lineProtein mislocalization: mechanisms, functions and clinical applications in cancer.MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation.Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer.Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures.A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors.MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signallingA noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loopMUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathwaymiR-1226 targets expression of the mucin 1 oncoprotein and induces cell death.Mucin-interacting proteins: from function to therapeutics.MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancerFunctional targeting of the MUC1 oncogene in human cancersSmall molecule inhibitors as probes for estrogen and androgen receptor actionMUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cellsMUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.The role of the small GTPase Rab31 in cancer.MUC1 oncoprotein promotes growth and survival of human multiple myeloma cells.The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice.Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse.MUC1 oncoprotein regulates Bcr-Abl stability and pathogenesis in chronic myelogenous leukemia cellsTargeting the intracellular MUC1 C-terminal domain inhibits proliferation and estrogen receptor transcriptional activity in lung adenocarcinoma cells.
P2860
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P2860
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
@en
type
label
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
@en
prefLabel
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
@en
P2093
P1433
P1476
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
@en
P2093
P304
P356
10.1016/J.MOLCEL.2005.11.030
P577
2006-01-01T00:00:00Z