Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. - Wikidata - wikimedia - TriplyDB

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.

http://www.wikidata.org/entity/Q40331276

about

The structure of the NPC1L1 N-terminal domain in a closed conformation Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation.Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.Molecular processes that handle -- and mishandle -- dietary lipids Cyclodextrin induces calcium-dependent lysosomal exocytosis Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine Proteins that bind and move lipids: MsbA and NPC1.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia Decreased NPC1L1 expression in the liver from Chinese female gallstone patients NPC1L1 and cholesterol transport Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1.Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels.SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin.C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver Protein mediators of sterol transport across intestinal brush border membrane.The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients.Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).Recent advances in small bowel diseases: Part II.Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid.Non-vesicular sterol transport in cells.Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.Mechanisms for cellular cholesterol transport: defects and human disease.Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia.Extracellular loop C of NPC1L1 is important for binding to ezetimibe Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis.Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters.Transporter-mediated uptake into cellular compartments.Development and physiological regulation of intestinal lipid absorption. III. Intestinal transporters and cholesterol absorption.

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P2860

Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake.

http://www.wikidata.org/entity/Q40331276

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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name

Cholesterol-regulated transloc ...... tates free cholesterol uptake.

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type

label

Cholesterol-regulated transloc ...... tates free cholesterol uptake.

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Cholesterol-regulated transloc ...... tates free cholesterol uptake.

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P1476

Cholesterol-regulated transloc ...... tates free cholesterol uptake.

@en

P2093

J Mark Brown

http://www.w3.org/2001/XMLSchema#string

Lawrence L Rudel

http://www.w3.org/2001/XMLSchema#string

Liqing Yu

http://www.w3.org/2001/XMLSchema#string

Mark C Willingham

http://www.w3.org/2001/XMLSchema#string

Matthew A Davis

http://www.w3.org/2001/XMLSchema#string

Peter Michaely

http://www.w3.org/2001/XMLSchema#string

Pingsheng Liu

http://www.w3.org/2001/XMLSchema#string

Shantaram Bharadwaj

http://www.w3.org/2001/XMLSchema#string

Wei Du

http://www.w3.org/2001/XMLSchema#string

Yinyan Ma

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P2860

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

WIF-B cells: an in vitro model for studies of hepatocyte polarity

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Ezetimibe selectively inhibits intestinal cholesterol absorption in rodents in the presence and absence of exocrine pancreatic function

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

Characterization of the putative native and recombinant rat sterol transporter Niemann-Pick C1 Like 1 (NPC1L1) protein

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

Endocytic recycling

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10

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281

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2005-12-30T00:00:00Z

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P698

16407187

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