Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
about
Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilinMarked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibitionClathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus.The NF2 tumor suppressor regulates microtubule-based vesicle trafficking via a novel Rac, MLK and p38(SAPK) pathway.The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartmentsRegulation of ErbB2 receptor status by the proteasomal DUB POH1.E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.Quality control for unfolded proteins at the plasma membrane.Geldanamycin selectively targets the nascent form of ERBB3 for degradationA kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.Antitumor activity of efrapeptins, alone or in combination with 2-deoxyglucose, in breast cancer in vitro and in vivoMechanisms of Trastuzumab resistance in ErbB2-driven breast cancer and newer opportunities to overcome therapy resistance.Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancerHepatocyte growth factor activator inhibitor-1 has a complex subcellular itineraryp130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancerA combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2.Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligandRegulation of ErbB2 localization and function in breast cancer cells by ERM proteinsSeptins: Regulators of Protein Stability.The Mysterious Ways of ErbB2/HER2 TraffickingSeptin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells.Flotillins as regulators of ErbB2 levels in breast cancer.A combination of Trastuzumab and 17-AAG induces enhanced ubiquitinylation and lysosomal pathway-dependent ErbB2 degradation and cytotoxicity in ErbB2-overexpressing breast cancer cells.Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.17AAG-induced internalisation of HER2-specific Affibody molecules.Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.The ERM Protein Moesin Regulates CD8(+) Regulatory T Cell Homeostasis and Self-Tolerance.Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.
P2860
Q28476397-69A20949-D4B8-4A6B-85B0-FA5E8A59EA4DQ28829301-022746FB-FC33-42AF-B255-4D63F1768E68Q30439237-229E0F78-AC08-4C24-ABB5-84CDC6831024Q30479942-8C0C88A4-A9FF-4630-A789-6984D08E1B37Q30606515-4F1F0AF2-CBCB-4E36-ACF8-554CCC99F73DQ31107044-FF5A75C9-1E15-4E19-88D2-EC561C77274EQ33444766-D8FB1A03-D0A1-464B-9A8A-EB53E5F0B848Q33606911-7637F8E4-AC65-4DFF-811E-30B3023FC32FQ34412404-62F96EA5-6347-4CC2-8D78-BA9DB0604C88Q34427505-0E35F61E-984E-49E6-93ED-F36EBEC6CB87Q34430965-01609A33-DB0E-461D-8377-F802C49FFAFCQ34472013-583E2FA8-4E72-4F1A-8177-F16103DD1853Q34690918-AC06DE25-D53A-4CE7-A7DB-65B5DD7540E5Q35624814-9E0A9BCC-09F4-4484-8C4E-C16A3F5DFAAEQ35930811-7F6D6471-EB14-4373-960A-077EF0A9E953Q36245418-BCAF193D-8E7E-4B2B-A29C-AA803988C913Q36498165-6DA3EDBA-677C-433E-83F5-3900E12B30ABQ36753781-81890276-FD48-498F-B338-5533BBE49E11Q36782465-281EBB4A-3219-4698-AFE6-50230DD663D3Q37089778-9F107332-79F1-4834-9695-3F4168D94BFEQ37251593-6C72BB60-588C-45B7-B4E3-6A11E41A0177Q37294882-4B60D3C9-1E8B-4936-A3A2-92548EEDC95AQ37295377-62754DAC-C8AF-4E50-A347-44B5DD151641Q37516409-C6900F54-B39C-4C27-83C7-29AB2DB7AD9AQ38237727-664885B4-2E09-4FB6-A329-D6607A45B544Q38780521-9527996A-ACD7-45E8-9160-B8C727773C9FQ39301423-84041F6B-53EF-4ED7-A033-D112B5A6BCE1Q39943622-1C369BFE-CF96-4B33-BDE9-A58C48557F47Q40061782-D4880592-FA9C-4403-8705-506DE3B39973Q40156909-F9C5A846-B19E-443A-8273-311CC575727DQ41197997-A9AE5FD6-88F8-4B97-9FB2-489F215B2F86Q41773399-4F798F47-9110-4EC6-8E00-7AEF230A6019Q41987459-B76C6548-390F-46C6-899C-0F81E7388344Q42516322-56944503-B968-4323-ADCA-54D617D6B4E0Q42801075-365241D1-C433-406E-87D5-C3747F01FD01Q51877889-F82F060D-D9EC-45A0-B3C4-CBADECCF7465
P2860
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
@en
type
label
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
@en
prefLabel
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
@en
P2093
P356
P1476
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way
@en
P2093
Anette M Hommelgaard
Bo van Deurs
Michael Grandal
P356
10.1242/JCS.02707
P407
P50
P577
2005-12-13T00:00:00Z