DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.
about
Explaining oscillations and variability in the p53-Mdm2 systemSpecific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitinationUbiquitin ligase ARF-BP1/Mule modulates base excision repairA novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityG2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localizationEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical examplePolycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancerStructural polymorphism in the N-terminal oligomerization domain of NPM1Phase separation in biology; functional organization of a higher orderInsights into the regulation of neuronal viability by nucleophosmin/B23Divorcing ARF and p53: an unsettled caseInvolvement of GLTSCR2 in the DNA Damage Response.GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARFNucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cellsCritical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.AKT regulates NPM dependent ARF localization and p53mut stability in tumors.Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repairCK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.A redox mechanism underlying nucleolar stress sensing by nucleophosminProtein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell linesp14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization.Topoisomerase-I PS506 as a Dual Function Cancer Biomarker.Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.Extracellular signal-regulated kinases modulate DNA damage response - a contributing factor to using MEK inhibitors in cancer therapy.Adenoviral protein V promotes a process of viral assembly through nucleophosmin 1.SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damageNMI mediates transcription-independent ARF regulation in response to cellular stressesNucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppressionTherapeutic targets in the ARF tumor suppressor pathway.Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activitiesDynamic intracellular distribution of Eaf2 and its potential involvement in UV-Induced DNA damage response.Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomasParp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.The Myc-nucleophosmin-ARF network: a complex web unveiled.The emerging role of Mule and ARF in the regulation of base excision repair.Base excision repair targets for cancer therapyFunctional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
P2860
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P2860
DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
DNA damage disrupts the p14ARF ...... lear redistribution of p14ARF.
@en
type
label
DNA damage disrupts the p14ARF ...... lear redistribution of p14ARF.
@en
prefLabel
DNA damage disrupts the p14ARF ...... lear redistribution of p14ARF.
@en
P2093
P1433
P1476
DNA damage disrupts the p14ARF ...... lear redistribution of p14ARF.
@en
P2093
Brian A Smith
Keya Bandyopadhyay
Ruth A Gjerset
P304
P356
10.1158/0008-5472.CAN-05-1759
P407
P577
2005-11-01T00:00:00Z