about
Fuzziness: linking regulation to protein dynamicsClassification of intrinsically disordered regions and proteinsCooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy ComplexMechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domainsTwo distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylationA first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection.MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 functionImpact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis.MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.Directed evolution of highly selective proteases by using a novel FACS-based screen that capitalizes on the p53 regulator MDM2Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53·MDM2/MDMX interaction.The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specificPre-structured motifs in the natively unstructured preS1 surface antigen of hepatitis B virus.The functional domains in p53 family proteins exhibit both common and distinct properties.Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.The MDM2-p53 pathway revisitedTargeting the p53 pathway.In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.Structural investigation on the intrinsically disordered N-terminal region of HPV16 E7 protein.TIP30 directly binds p53 tumor suppressor protein in vitro.Transcriptional switches: chemical approaches to gene regulationOverexpression of p53 protein in human tumors.Backbone dynamics of the 18.5 kDa isoform of myelin basic protein reveals transient alpha-helices and a calmodulin-binding site.The alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins.Design of p53-derived peptides with cytotoxicity on breast cancer.The Transactivation Domains of the p53 Protein.Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugsStabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination.Long-range modulation of chain motions within the intrinsically disordered transactivation domain of tumor suppressor p53.Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus.Transcription factor effector domains.Free energy evaluation of the p53-Mdm2 complex from unbinding work measured by dynamic force spectroscopy.Surface Plasmon Resonance Sensing of Biorecognition Interactions within the Tumor Suppressor p53 Network.An NMR study on the intrinsically disordered core transactivation domain of human glucocorticoid receptor.C-terminal region of human p53 attenuates buffalo p53 N-terminal-specific transactivation of p21 promoter by modulating tetramerization of the protein.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Structural details on mdm2-p53 interaction.
@en
type
label
Structural details on mdm2-p53 interaction.
@en
prefLabel
Structural details on mdm2-p53 interaction.
@en
P2093
P2860
P356
P1476
Structural details on mdm2-p53 interaction.
@en
P2093
Do-Hyoung Kim
Jae-Sung Kim
Jin-Young Woo
Kyou-Hoon Han
Masatsune Kainosho
Min-Jung Ahn
Seung-Wook Chi
Si-Hyung Lee
Takuya Torizawa
P2860
P304
38795-38802
P356
10.1074/JBC.M508578200
P407
P577
2005-09-13T00:00:00Z