c-Myb regulates the proliferation of immature thymocytes following beta-selection.
about
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell developmentConditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiationCritical functions for c-Myb at three checkpoints during thymocyte development.The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.Transgenic analysis of thymocyte signal transduction.Alu elements mediate MYB gene tandem duplication in human T-ALLc-Myb a stem-progenitor cell regulator in multiple tissue compartments.Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.Mechanisms of transcription factor deregulation in lymphoid cell transformation.Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.Role and potential for therapeutic targeting of MYB in leukemia.Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.Myb proteins regulate expression of histone variant H2A.Z during thymocyte development.c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.c-Myc mediates pre-TCR-induced proliferation but not developmental progressionc-Myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression.The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.C-myb Plays an Essential Role in the Protective Function of IGF-1 on Cytotoxicity Induced by Aβ25-35 via the PI3K/Akt Pathway.Defining the specific physiological requirements for c-Myc in T cell development.
P2860
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P2860
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
description
2000 nî lūn-bûn
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name
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
@en
type
label
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
@en
prefLabel
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
@en
P2860
P356
P1433
P1476
c-Myb regulates the proliferation of immature thymocytes following beta-selection.
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.22.6112
P407
P577
2000-11-01T00:00:00Z