Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. - Wikidata - wikimedia - TriplyDB

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.

http://www.wikidata.org/entity/Q40399370

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PI3K/AKT/mTOR Pathway in Angiogenesis Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Cancer immunoediting from immune surveillance to immune escape The potential of radiotherapy to enhance the efficacy of renal cell carcinoma therapy SOCS, inflammation, and cancer Signal transducer and activator of transcription 3 (STAT3) signaling in retinal pigment epithelium cells Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1 and Stimulates the Synthesis of Vascular Endothelial Growth Factor Molecular targets of isothiocyanates in cancer: recent advances Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells STAT3 negatively regulates thyroid tumorigenesis HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells Breaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkers Multiple strategies of oxygen supply in Drosophila malignancies identify tracheogenesis as a novel cancer hallmark Role of STAT3 in cancer metastasis and translational advances.Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation.Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.SOCS3 inhibits the pathological effects of IL-22 in non-melanoma skin tumor-derived keratinocytes Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.MicroRNA-1299 is a negative regulator of STAT3 in colon cancer Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.Gender dimorphisms in progenitor and stem cell function in cardiovascular disease.STAT3, p-STAT3 and HIF-1α are associated with vasculogenic mimicry and impact on survival in gastric adenocarcinoma Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines.STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3.Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.

http://www.wikidata.org/entity/Q40399370

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2005 nî lūn-bûn

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2005年论文

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2005年论文

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2005年论文

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name

Targeting Stat3 blocks both HI ...... nic growth signaling pathways.

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Targeting Stat3 blocks both HI ...... nic growth signaling pathways.

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Targeting Stat3 blocks both HI ...... nic growth signaling pathways.

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Targeting Stat3 blocks both HI ...... nic growth signaling pathways.

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Guilian Niu

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Heidi Kay

http://www.w3.org/2001/XMLSchema#string

Hua Yu

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James Turkson

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Jin Q Cheng

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Jon Briggs

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Marcin Kortylewski

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Qing Xu

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Richard Jove

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Shumin Zhang

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P2860

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Targeting HIF-1 for cancer therapy

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

The STATs of cancer--new molecular targets come of age

JAKs, STATs and Src kinases in hematopoiesis.

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression.

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5552-5560

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scholarly article

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10.1038/SJ.ONC.1208719

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36

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24

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Gregg L. Semenza

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2005-08-01T00:00:00Z

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232748668

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1044728544

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16007214

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