HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
about
The anti-addiction drug ibogaine and the heart: a delicate relationEvaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.hERG-related drug toxicity and models for predicting hERG liability and QT prolongation.HERG1 channelopathiesMultiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells.Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2.Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice.Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.Endocytosis of HERG is clathrin-independent and involves arf6.Molecular determinants of pentamidine-induced hERG trafficking inhibition.High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds.In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarialsCombined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.Novel intramolecular photoinduced electron transfer-based probe for the Human Ether-a-go-go-Related Gene (hERG) potassium channel.Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk.Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.Innovative approaches to anti-arrhythmic drug therapy.New cell models and assays in cardiac safety profiling.Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Interaction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stabilityStrategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective.Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane.An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing riskPredicting drug-induced QT prolongation and torsades de pointes: a review of preclinical endpoint measures.A 2015 focus on preventing drug-induced arrhythmias.Cardiotoxicity screening: a review of rapid-throughput in vitro approaches.Natural products modulating the hERG channel: heartaches and hope.Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry.A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.The hERG channel is dependent upon the Hsp90α isoform for maturation and trafficking.Effect of microculture on cell metabolism and biochemistry: do cells get stressed in microchannels?High-content screening of drug-induced cardiotoxicity using quantitative single cell imaging cytometry on microfluidic device.Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines.
P2860
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P2860
HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
@en
type
label
HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
@en
prefLabel
HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
@en
P2093
P1476
HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.
@en
P2093
Arthur M Brown
Barbara A Wible
Eckhard Ficker
Glenn Kirsch
Peter Hawryluk
Yuri A Kuryshev
P304
P356
10.1016/J.VASCN.2005.03.008
P577
2005-07-01T00:00:00Z