Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
about
M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer modelsThe synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrenceTumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells--a preclinical MR study in mice.Combining mTOR inhibition with radiation improves antitumor activity in bladder cancer cells in vitro and in vivo: a novel strategy for treatment.RTOG 0913: a phase 1 study of daily everolimus (RAD001) in combination with radiation therapy and temozolomide in patients with newly diagnosed glioblastoma.Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells.Biomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further ProposalsRadiosensitization of solid tumors by Z-VAD, a pan-caspase inhibitor.Anti-Angiogenic/Vascular Effects of the mTOR Inhibitor Everolimus Are Not Detectable by FDG/FLT-PETRas/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risksNorth Central Cancer Treatment Group Phase I trial N057K of everolimus (RAD001) and temozolomide in combination with radiation therapy in patients with newly diagnosed glioblastoma multiforme.Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer.Mammalian target of rapamycin and head and neck squamous cell carcinomaA phase 1b trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies.Autophagy in tumor suppression and cancer therapy.The mTOR inhibitor rapamycin suppresses DNA double-strand break repairRas/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cellsPreclinical evaluation of injectable sirolimus formulated with polymeric nanoparticle for cancer therapyDual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells.Mammalian target of rapamycin inhibitor RAD001 sensitizes endometrial cancer cells to paclitaxel-induced apoptosis via the induction of autophagy.Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235mTOR Inhibitors in Tuberous Sclerosis Complex.Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment.NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers.Everolimus: an immunosuppressive agent in transplantation.Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis.Investigating mammalian target of rapamycin inhibitors for their anticancer properties.Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.Inhibiting kinases in malignant gliomas.Combining molecular targeted agents with radiation therapy for malignant gliomasCombined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model.Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma.Regulation of protein synthesis by ionizing radiation.The role of apoptosis in radiation oncology.
P2860
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P2860
Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
@en
type
label
Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
@en
prefLabel
Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
@en
P2093
P356
P1433
P1476
Enhanced radiation damage of tumor vasculature by mTOR inhibitors.
@en
P2093
Carolyn Cao
Dennis E Hallahan
Eric T Shinohara
Fenghua Zeng
Ken Niermann
P2888
P304
P356
10.1038/SJ.ONC.1208715
P407
P577
2005-08-01T00:00:00Z
P5875
P6179
1007447413