Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
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Integration of the extranuclear and nuclear actions of estrogenBisphosphonates: mechanism of action and role in clinical practiceGap junctional regulation of signal transduction in bone cellsApoptotic osteocytes and the control of targeted bone resorptionConnexin 43 hemichannels and intracellular signaling in bone cellsAmerican Society of Biomechanics Journal of Biomechanics Award 2013: cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures.Bisphosphonates: from bench to bedsideNormal bone anatomy and physiologyInsulin receptor substrate 2 plays important roles in 17beta-estradiol-induced bone formationIdentification of B cells participated in the mechanism of postmenopausal women osteoporosis using microarray analysisSystemic zoledronate treatment both prevents resorption of allograft bone and increases the retention of new formed bone during revascularization and remodelling. A bone chamber study in rats.Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferationXenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT.Interleukin-1beta increases gap junctional communication among synovial fibroblasts via the extracellular-signal-regulated kinase pathway.Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis.Effect of bisphosphonates on the progression of degenerative aortic stenosis.RANKL inhibition improves bone properties in a mouse model of osteogenesis imperfecta.Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability.A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice.A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosisOsteoblastic cell secretome: a novel role for progranulin during risedronate treatmentEstrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor-mediated expression of beta1-integrin.Cx43 and mechanotransduction in bone.Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormonePathogenesis of aortic stenosis: not just a matter of wear and tearPro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and IIRecommendations for Diagnosis and Management of Osteoporosis in COPD Men.Prolonged treatments with antiresorptive agents and PTH have different effects on bone strength and the degree of mineralization in old estrogen-deficient osteoporotic rats.Connexins and pannexins in the skeleton: gap junctions, hemichannels and moreERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts.Osteocyte signaling in boneCONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.Effect of raloxifene treatment on osteocyte apoptosis in postmenopausal women.Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.Beyond gap junctions: Connexin43 and bone cell signalingThe gap junction cellular internet: connexin hemichannels enter the signalling limelightActivated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonatesCrosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransductionCell-cell communication in the osteoblast/osteocyte lineage.
P2860
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P2860
Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
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2004年學術文章
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name
Bisphosphonates and estrogens ...... l-regulated kinase activation.
@en
type
label
Bisphosphonates and estrogens ...... l-regulated kinase activation.
@en
prefLabel
Bisphosphonates and estrogens ...... l-regulated kinase activation.
@en
P2093
P2860
P356
P1476
Bisphosphonates and estrogens ...... l-regulated kinase activation.
@en
P2093
J Ignacio Aguirre
Lilian I Plotkin
Stavros C Manolagas
Stavroula Kousteni
P2860
P304
P356
10.1074/JBC.M412817200
P407
P577
2004-12-06T00:00:00Z