Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. - Wikidata - wikimedia - TriplyDB

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

http://www.wikidata.org/entity/Q40485180

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HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2 Effects of MdmX on Mdm2-mediated downregulation of pRB Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein MDM2 regulates dihydrofolate reductase activity through monoubiquitination The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake Twists in views on RB functions in cellular signaling, metabolism and stem cells Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein Hdmx modulates the outcome of p53 activation in human tumor cells Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.Therapeutic considerations for Mdm2: not just a one trick pony TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein.Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.Screening E3 substrates using a live phage display library Dynamic regulation of PCNA ubiquitylation/deubiquitylation.A comprehensive method for detecting ubiquitinated substrates using TR-TUBE.Eye cancer: unique insights into oncogenesis: the Cogan Lecture.Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops.The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance.The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Mdm2 in growth signaling and cancer.A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.Regulation of the G1/S phase of the cell cycle and alterations in the RB pathway in human lung cancer.Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function.Pocket protein function in melanocyte homeostasis and neoplasia.A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation The MDM2-p53 pathway revisited MdmX regulates transformation and chromosomal stability in p53-deficient cells.The human papillomavirus E7 oncoprotein.Long Non-Coding RNAs Embedded in the Rb and p53 Pathways Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.

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P2860

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

http://www.wikidata.org/entity/Q40485180

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2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

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type

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

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SJ.EMBOJ.7600486

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The EMBO Journal

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Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

@en

P2093

Chiharu Uchida

http://www.w3.org/2001/XMLSchema#string

Haruhiko Sugimura

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Hideyo Yasuda

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Keizou Ookawa

http://www.w3.org/2001/XMLSchema#string

Kyoko Kitagawa

http://www.w3.org/2001/XMLSchema#string

Masatoshi Kitagawa

http://www.w3.org/2001/XMLSchema#string

Seiichi Miwa

http://www.w3.org/2001/XMLSchema#string

Sunao Otani

http://www.w3.org/2001/XMLSchema#string

Takayuki Hattori

http://www.w3.org/2001/XMLSchema#string

Takehiko Kamijo

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P2860

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Interaction between the retinoblastoma protein and the oncoprotein MDM2

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

The retinoblastoma protein and cell cycle control

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

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1

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2004-12-02T00:00:00Z

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8149733

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15577944

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544902

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