Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeNatural history of β-cell adaptation and failure in type 2 diabetesSilencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionAcute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysPTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cellsInhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachSynchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.Glucose infusion in mice: a new model to induce beta-cell replication.Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in miceAkt and PTEN: beta-cell mass and pancreas plasticity.Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistanceKalirin/Trio Rho guanine nucleotide exchange factors regulate a novel step in secretory granule maturationIncreased fetal insulin concentrations for one week fail to improve insulin secretion or β-cell mass in fetal sheep with chronically reduced glucose supplyInsulin stimulates primary beta-cell proliferation via Raf-1 kinase.The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathwaysInsulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activationGene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growthBeta-cell failure as a complication of diabetes.Growth factor control of pancreatic islet regeneration and functionGlucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorMicroenvironmental stimuli for proliferation of functional islet β-cells.Curcumin improves high glucose-induced INS-1 cell insulin resistance via activation of insulin signaling.CDK4, pRB and E2F1: connected to insulin.Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells.Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response.Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.Knocking down Insulin Receptor in Pancreatic Beta Cell lines with Lentiviral-Small Hairpin RNA Reduces Glucose-Stimulated Insulin Secretion via Decreasing the Gene Expression of Insulin, GLUT2 and Pdx1.The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells.
P2860
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P2860
Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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2004年學術文章
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name
Reduced expression of the insu ...... nsulin content, and secretion.
@en
type
label
Reduced expression of the insu ...... nsulin content, and secretion.
@en
prefLabel
Reduced expression of the insu ...... nsulin content, and secretion.
@en
P2093
P2860
P356
P1476
Reduced expression of the insu ...... nsulin content, and secretion.
@en
P2093
Ernesto Bernal-Mizrachi
James D Johnson
Kenneth S Polonsky
M Alan Permutt
Mitsuru Ohsugi
Yiyong Zhou
P2860
P304
P356
10.1074/JBC.M411727200
P407
P577
2004-11-15T00:00:00Z