Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
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Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1Thyroid hormone T3 counteracts STZ induced diabetes in mouseDifferential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expressionSilencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionInsulin signaling regulates mitochondrial function in pancreatic beta-cellsPancreatic β-cell proliferation in obesity.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysGlucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesInsulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.Insulin enhances glucose-stimulated insulin secretion in healthy humansInsulin and glucagon regulate pancreatic α-cell proliferationGABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells.Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitusPalmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathwayLoss of TRB3 alters dynamics of MLK3-JNK signaling and inhibits cytokine-activated pancreatic beta cell death.Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscleCannabinoids inhibit insulin receptor signaling in pancreatic β-cells.Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids.Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans.RNA-binding protein HuD controls insulin translationChemical methods to induce Beta-cell proliferation.ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell ProliferationChanges in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin.Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation.Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in miceAnti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function.Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression.IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanismsInsulin and hyperandrogenism in women with polycystic ovary syndrome.The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes.Mild hyperglycemia triggered islet function recovery in streptozotocin-induced insulin-deficient diabetic rats.Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin ReceptorMST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling.
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P2860
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Glucose effects on beta-cell g ...... insulin receptor substrate 2.
@en
type
label
Glucose effects on beta-cell g ...... insulin receptor substrate 2.
@en
prefLabel
Glucose effects on beta-cell g ...... insulin receptor substrate 2.
@en
P2093
P2860
P356
P1476
Glucose effects on beta-cell g ...... insulin receptor substrate 2.
@en
P2093
Anke Assmann
Jonathon N Winnay
Rohit N Kulkarni
Takahashi Kadowaki
P2860
P304
P356
10.1128/MCB.01489-08
P407
P50
P577
2009-03-09T00:00:00Z