Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.
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Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesThe sensitivity of the Ewing's sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1-dependent modulation of p38(MAPK) activityMammalian target of rapamycin is essential for cardiomyocyte survival and heart development in miceRapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.Primary sarcoma of the liver and transplantation: a case study and literature reviewFrontier of epilepsy research - mTOR signaling pathway.AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradationMammalian target of rapamycin and head and neck squamous cell carcinomaDisruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALLNegative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.Cell death signaling and anticancer therapyInhibitors of the mammalian target of rapamycin.Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivoCryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cellsCelastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway.Diabetes diminishes phosphatidic acid in the retina: a putative mediator for reduced mTOR signaling and increased neuronal cell death.Knockdown of protein phosphatase 5 inhibits ovarian cancer growth in vitro.Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancerElevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancerRapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A.Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB)4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells.JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcomaDanshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling.Novel Ser/Thr protein phosphatases in cell death regulationThe targets of curcumin.The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.Hitting the golden TORget: curcumin's effects on mTOR signaling.The role of mitochondria in mTOR-regulated longevity.Protein phosphatases in pancreatic islets.Structurally related hydrazone-based metal complexes with different antitumor activities variably induce apoptotic cell death.Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK.Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth.Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma.Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.
P2860
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P2860
Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Inhibition of mammalian target ...... rotein phosphatase 5 activity.
@en
type
label
Inhibition of mammalian target ...... rotein phosphatase 5 activity.
@en
prefLabel
Inhibition of mammalian target ...... rotein phosphatase 5 activity.
@en
P2093
P50
P356
P1476
Inhibition of mammalian target ...... rotein phosphatase 5 activity.
@en
P2093
Franklin C Harwood
Glen S Germain
Peter J Houghton
P304
36490-36496
P356
10.1074/JBC.M401208200
P407
P577
2004-06-24T00:00:00Z