Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila.
about
Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ringSMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayDegradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayIdentification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNAThe zinc-finger antiviral protein recruits the RNA processing exosome to degrade the target mRNAA crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processingStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexNonsense-mediated mRNA decay: novel mechanistic insights and biological impactMechanisms of deadenylation-dependent decayThe Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality ControlStructure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA DecayThe crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosomeEndonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation.Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p.A convergence of rRNA and mRNA quality control pathways revealed by mechanistic analysis of nonfunctional rRNA decayRole for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Targeting of aberrant mRNAs to cytoplasmic processing bodies.Nonsense-mediated mRNA decay in humans at a glanceHow and where are nonsense mRNAs degraded in mammalian cells?Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci.Structured RNAs that evade or confound exonucleases: function follows form.Novel roles of the multi-functional CCR4-NOT complex in post-transcriptional regulation.The exozyme model: a continuum of functionally distinct complexes.Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1.The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.Genome-wide analysis of mRNA decay patterns during early Drosophila development.A post-translational regulatory switch on UPF1 controls targeted mRNA degradationUnder the Tucson sun: a meeting in the desert on mRNA decay.Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosomeNonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs.Differential utilization of decapping enzymes in mammalian mRNA decay pathways.A quantitative assay for measuring mRNA decapping by splinted ligation reverse transcription polymerase chain reaction: qSL-RT-PCR
P2860
Q21562658-EC15958B-3850-4B6B-8858-77DB886E06B6Q24302039-9E8FBA49-33AF-4C0A-956E-351053CD94EDQ24305376-6A85C08F-8579-4CEE-9791-74A9E8EAAD4AQ24310484-2107624C-2936-41DC-AFD9-693F520B8D69Q24311198-8E0BF8AC-A2BE-4879-8CED-AD1BC0AAAAFCQ24314490-DFC2E0A7-9E13-4828-AFD1-C8E43070F200Q24319977-F6D2EF85-6CD9-4675-874E-BE63F11CA168Q24337846-A6C90F44-8B72-4A82-9432-4A4B9E39B3B4Q24537488-EDC22D9B-864E-449A-9189-E78AF33ABB8EQ24675358-5F916E94-4D15-40F7-A5BA-A43CC01797C6Q24676384-B20D9CBF-C9F3-4B7E-8F2C-311E74FFCB11Q26750271-F9941F0C-F07A-4926-8B70-EEFC5865746AQ26829435-F29DBEBF-A317-438F-AE08-221EABB36E55Q27027216-E9869986-74BA-4F1E-9944-84E6F436E7F2Q27653658-FFFF763E-451C-4FA5-9B41-9765F5F7DC14Q27666866-0C6B32AC-67DC-4037-9CB7-5BA3937C41CDQ27667115-DCCAD4C1-84AE-48E6-8AAF-8817C6E98F3EQ27675788-8035DE6A-0DB2-44D4-835D-2EE4AC71C116Q27932697-6DB7C036-270A-4DE9-BECF-40740122EA15Q27932846-1486543F-9014-4CF9-9928-81384530B73EQ27934461-CCE6E747-1CF2-4A94-A63F-1840A3B1161CQ27935545-6DD5AA81-82AC-442F-B3F3-B55DFE01C3C7Q27939158-81FBC1F5-6C33-4517-9AB0-8002E2DB61C2Q28077157-53DF2BF1-37C1-4B70-AD11-8FD013455B59Q28636081-7D89B95A-0B6B-4F2B-8C2F-63598861D5DCQ30476869-1ECE9E44-13F3-41FE-82A5-E154DED740BBQ33552854-958315E7-3CCD-4F03-AC6C-717E9983B7ABQ33658496-E29EEC66-5AF2-420E-970C-F8236DB26930Q34024670-A4D36034-F2D8-482C-BB16-C5B25A2CDBBBQ34064226-C5638391-9D4A-441C-9091-213FC2DA3124Q34129489-AA8E6BD5-0AD5-4459-AB9E-2900908156A4Q34247597-4F8FF134-F955-4F6A-BC58-63A8C250B2DCQ34342871-FE0FF7E7-322F-4A3F-8A49-3DF8EF05C7A5Q34366114-A61783A1-54A5-472C-8AB8-D5ADEBA382DEQ34366308-3F501F58-700E-4A4B-80E5-7054E74CB9ABQ34366609-5409C9E3-3E17-4D75-989D-34E5819CF5D2Q34518964-39284038-40F9-4BE8-8E21-2D5772C34D16Q34573247-44E2977E-DB0E-499C-9071-AE2BBD7552B6Q34574859-0E9A3EF2-3421-47BF-B186-F70940AD13F5Q34574887-DCC33E3A-12BF-40B7-8388-08F256B74C60
P2860
Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Nonsense-mediated messenger RN ...... olytic cleavage in Drosophila.
@en
type
label
Nonsense-mediated messenger RN ...... olytic cleavage in Drosophila.
@en
prefLabel
Nonsense-mediated messenger RN ...... olytic cleavage in Drosophila.
@en
P2860
P356
P1433
P1476
Nonsense-mediated messenger RN ...... olytic cleavage in Drosophila.
@en
P2860
P2888
P304
P356
10.1038/NATURE02559
P407
P577
2004-06-01T00:00:00Z
P6179
1000910611