Chemical genetic control of protein levels: selective in vivo targeted degradation.
about
Targeting the androgen receptor with steroid conjugatesTargeting proteins for degradationConformational switching of the 26S proteasome enables substrate degradationDRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationDegrons of yeast and mammalian ornithine decarboxylase enzymes make potent combination for regulated targeted protein degradation.Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cellsThe ubiquitin system, disease, and drug discovery.Targeting the undruggable proteome: the small molecules of my dreams.Nucleating the assembly of macromolecular complexes.Protacs for treatment of cancer.Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.Catalytic in vivo protein knockdown by small-molecule PROTACs.A functionally orthogonal ligand-receptor pair created by targeting the allosteric mechanism of the thyroid hormone receptor.Induced protein degradation: an emerging drug discovery paradigm.Effective molarity redux: Proximity as a guiding force in chemistry and biology.Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomicsSmall-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins.Chemical biology strategies for posttranslational control of protein function.Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic TaggingChemical approaches to controlling intracellular protein degradation.Small-molecule-mediated rescue of protein function by an inducible proteolytic shuntChemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwayJostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs.Degradation and beyond: control of androgen receptor activity by the proteasome system.Chemical crosshairs on the central dogma.Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs.Natural products: chemical instruments to apprehend biological symphony.Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cellsRewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitinationPROTAC-induced proteolytic targeting.Two-headed PROTAC: an effective new tool for targeted protein degradationLoss-of-function genetic tools for animal models: cross-species and cross-platform differences.Protein tango: the toolbox to capture interacting partners.The ends and means of artificially induced targeted protein degradation.Frontiers of protein expression control with conditional degrons.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system
P2860
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P2860
Chemical genetic control of protein levels: selective in vivo targeted degradation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Chemical genetic control of protein levels: selective in vivo targeted degradation.
@en
type
label
Chemical genetic control of protein levels: selective in vivo targeted degradation.
@en
prefLabel
Chemical genetic control of protein levels: selective in vivo targeted degradation.
@en
P2093
P356
P1476
Chemical genetic control of protein levels: selective in vivo targeted degradation.
@en
P2093
Amit Mandal
Craig M Crews
Fabiana N Fonseca
John S Schneekloth
Kathleen Sakamoto
Michael Koldobskiy
Raymond Deshaies
P304
P356
10.1021/JA039025Z
P407
P577
2004-03-01T00:00:00Z