Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. - Wikidata - wikimedia - TriplyDB

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

http://www.wikidata.org/entity/Q40577621

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Werner syndrome protein interacts functionally with translesion DNA polymerases Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors The Werner syndrome protein: linking the replication checkpoint response to genome stability Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology Roles of Werner syndrome protein in protection of genome integrity Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging Human premature aging, DNA repair and RecQ helicases The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.The role of RecQ helicases in non-homologous end-joining RecQ helicases in DNA double strand break repair and telomere maintenance.A novel function for the Mre11-Rad50-Xrs2 complex in base excision repair.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair WRN regulates pathway choice between classical and alternative non-homologous end joining Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks.Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.WRN participates in translesion synthesis pathway through interaction with NBS1 Analysis of MRE11's function in the 5'-->3' processing of DNA double-strand breaks DNA repair deficiency in neurodegeneration.The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.Telomeres, chromosome instability and cancer Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes.Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair.Human RecQ helicases in DNA repair, recombination, and replication.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress.Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance Contributions of DNA interstrand cross-links to aging of cells and organisms.Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy.Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone MRE11 complex links RECQ5 helicase to sites of DNA damage.

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P2860

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

http://www.wikidata.org/entity/Q40577621

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

@en

type

label

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

@en

prefLabel

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

@en

P1433

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P1433

Journal of Biological Chemistry

P1476

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

@en

P2093

Cayetano von Kobbe

http://www.w3.org/2001/XMLSchema#string

James P Carney

http://www.w3.org/2001/XMLSchema#string

Kenshi Komatsu

http://www.w3.org/2001/XMLSchema#string

L Matthew Arthur

http://www.w3.org/2001/XMLSchema#string

Michael M Seidman

http://www.w3.org/2001/XMLSchema#string

Patricia L Opresko

http://www.w3.org/2001/XMLSchema#string

Vilhelm A Bohr

http://www.w3.org/2001/XMLSchema#string

Wen-Hsing Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

The Werner syndrome protein is a DNA helicase

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

P304

21169-21176

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scholarly article

P356

10.1074/JBC.M312770200

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P407

P433

20

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P478

279

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P577

2004-03-16T00:00:00Z

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P698

15026416

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