Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
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Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applicationsMolecular details of cAMP generation in mammalian cells: a tale of two systemsBacillus anthracis edema factor substrate specificity: evidence for new modes of actionCrystal structure of the guanylyl cyclase Cya2Intracellular cAMP signaling by soluble adenylyl cyclase.Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth conesSoluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1Novel inhibitors of anthrax edema factor.Structure-based development of novel adenylyl cyclase inhibitorsA new signalling pathway for parallel fibre presynaptic type 4 metabotropic glutamate receptors (mGluR4) in the rat cerebellar cortex.Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin.Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.Structural basis for the high-affinity inhibition of mammalian membranous adenylyl cyclase by 2',3'-o-(N-methylanthraniloyl)-inosine 5'-triphosphate.The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cellsInhibitors of membranous adenylyl cyclases.Role of soluble adenylyl cyclase in the heart.A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitorsGlucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells.Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.Pharmacological distinction between soluble and transmembrane adenylyl cyclases.Nucleotide regulation of soluble guanylate cyclase substrate specificity.Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.Allosteric regulation of nucleotidyl cyclases: an emerging pharmacological target.An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.Impact of divalent metal ions on regulation of adenylyl cyclase isoforms by forskolin analogs.Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases.Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.Nitric oxide activation of guanylate cyclase pushes the α1 signaling helix and the β1 heme-binding domain closer to the substrate-binding site.Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphatesDifferential interactions of the catalytic subunits of adenylyl cyclase with forskolin analogs.Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes.Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.Adenylyl and guanylyl cyclase assays.Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats.Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
P2860
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P2860
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Differential inhibition of ade ...... ne and pyrimidine nucleotides.
@en
type
label
Differential inhibition of ade ...... ne and pyrimidine nucleotides.
@en
prefLabel
Differential inhibition of ade ...... ne and pyrimidine nucleotides.
@en
P2093
P2860
P356
P1476
Differential inhibition of ade ...... ine and pyrimidine nucleotides
@en
P2093
Michael B Doughty
Roger A Johnson
Roland Seifert
Tung-Chung Mou
P2860
P304
19955-19969
P356
10.1074/JBC.M312560200
P407
P577
2004-02-23T00:00:00Z