Role of Bim in the survival pathway induced by Raf in epithelial cells. - Wikidata - wikimedia - TriplyDB

Role of Bim in the survival pathway induced by Raf in epithelial cells.

Role of Bim in the survival pathway induced by Raf in epithelial cells.

http://www.wikidata.org/entity/Q40607194

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PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity N-cadherin mediates neuronal cell survival through Bim down-regulation.Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis.Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons.Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells Gene transfer: Bax to the future for cancer therapy.ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo.Roles of apoptosis in airway epithelia.Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development.Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim.BCL-2 family regulation by the 20S proteasome inhibitor bortezomib.Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells.Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology.uPAR peptide antagonist alters regulation of MAP kinases and Bcl-2 family members in favor of apoptosis in MDA-MB-231 cell line Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types.The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability.Targeting the regulatory machinery of BIM for cancer therapy.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.Exoenzyme S of Pseudomonas aeruginosa is not able to induce apoptosis when cells express activated proteins, such as Ras or protein kinase B/Akt.Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.

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P2860

Role of Bim in the survival pathway induced by Raf in epithelial cells.

http://www.wikidata.org/entity/Q40607194

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Role of Bim in the survival pathway induced by Raf in epithelial cells.

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type

label

Role of Bim in the survival pathway induced by Raf in epithelial cells.

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prefLabel

Role of Bim in the survival pathway induced by Raf in epithelial cells.

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Role of Bim in the survival pathway induced by Raf in epithelial cells.

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P2093

David Hancock

http://www.w3.org/2001/XMLSchema#string

Michela Marani

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Nicholas R Lemoine

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Rita Lopes

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Tencho Tenev

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P2860

Disruption of epithelial cell-matrix interactions induces apoptosis

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells.

Adhesion-mediated signaling in the regulation of mammary epithelial cell survival.

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression.

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity.

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor.

Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway.

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2431-2441

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10.1038/SJ.ONC.1207364

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14

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23

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Julian Downward

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2004-04-01T00:00:00Z

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8958065

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1002500415

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14676826

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