Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing
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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesInvolvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucoseMolecular physiology of mammalian glucokinaseInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeClass II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cellsMyosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cellsA feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysGlucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesFoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells.Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cellsTranscriptional regulation of glucose sensors in pancreatic β-cells and liver: an update.Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistanceDisruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathwaysRegulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.Mathematical models for insulin secretion in pancreatic β-cells.Modulation of β-cell function: a translational journey from the bench to the bedside.Minireview: intraislet regulation of insulin secretion in humans.Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors.Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).Clone-derived human AF-amniotic fluid stem cells are capable of skeletal myogenic differentiation in vitro and in vivo.PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells.Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.siRNA produced by recombinant dicer mediates efficient gene silencing in islet cells.Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicityPKClambda regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic beta cells.Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.Temporal changes in endometrial gene expression and protein localization of members of the IGF family in cattle: effects of progesterone and pregnancy.Glucose is necessary for embryonic pancreatic endocrine cell differentiation.
P2860
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P2860
Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Distinct roles for insulin and ...... sing revealed by RNA silencing
@en
type
label
Distinct roles for insulin and ...... sing revealed by RNA silencing
@en
prefLabel
Distinct roles for insulin and ...... sing revealed by RNA silencing
@en
P2860
P356
P1433
P1476
Distinct roles for insulin and ...... sing revealed by RNA silencing
@en
P2093
Guy A Rutter
Qingwen Qian
P2860
P304
P356
10.1042/BJ20031260
P407
P577
2004-01-01T00:00:00Z