Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysNovel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.Metal complexes as potential modulators of inflammatory and autoimmune responses.Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsMn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumorsAnticancer therapeutic potential of Mn porphyrin/ascorbate systemCytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).Mitochondrial metals as a potential therapeutic target in neurodegeneration.Simple biological systems for assessing the activity of superoxide dismutase mimics.Manganese superoxide dismutase, MnSOD and its mimicsDesign, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators.Therapeutic potential of peroxynitrite decomposition catalysts: a patent review.Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications.Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.
P2860
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P2860
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Methoxy-derivatization of alky ...... methoxyalkylpyridylporphyrins.
@en
type
label
Methoxy-derivatization of alky ...... methoxyalkylpyridylporphyrins.
@en
prefLabel
Methoxy-derivatization of alky ...... methoxyalkylpyridylporphyrins.
@en
P2093
P2860
P50
P356
P1433
P1476
Methoxy-derivatization of alky ...... -methoxyalkylpyridylporphyrins
@en
P2093
Daniela Salvemini
David S Warner
Huaxin Sheng
Ines Batinic-Haberle
Ivan Spasojevic
Zrinka Rajic
P2860
P304
P356
10.1039/C0DT01321H
P407
P577
2011-03-08T00:00:00Z