Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways.
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New Insights into Wnt-Lrp5/6-β-Catenin Signaling in MechanotransductionSost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activationDynamic acoustic radiation force retains bone structural and mechanical integrity in a functional disuse osteopenia modelPhysicochemical control of adult stem cell differentiation: shedding light on potential molecular mechanisms.Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblastsLnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependentSignal transduction and mechanical stress.A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?Molecular pathways mediating mechanical signaling in bone.Steady and oscillatory fluid flows produce a similar osteogenic phenotype.Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells.Estrogen receptor-β regulates mechanical signaling in primary osteoblasts.The influence of environmental factors on bone tissue engineering.Is interaction between age-dependent decline in mechanical stimulation and osteocyte-estrogen receptor levels the culprit for postmenopausal-impaired bone formation?Review of biophysical factors affecting osteogenic differentiation of human adult adipose-derived stem cells.Fluoride affects calcium homeostasis and osteogenic transcription factor expressions through L-type calcium channels in osteoblast cell line.Influence of cassette design on three-dimensional perfusion culture of artificial bone.Intermittent traction stretch promotes the osteoblastic differentiation of bone mesenchymal stem cells by the ERK1/2-activated Cbfa1 pathway.Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin.Effects of IGF-II on promoting proliferation and regulating nitric oxide synthase gene expression in mouse osteoblast-like cell.Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.Pertussis toxin-sensitive Galphai protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts.Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading.A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation.ERK activation is required for hydrostatic pressure-induced tensile changes in engineered articular cartilage.Adaptive responses of murine osteoblasts subjected to coupled mechanical stimuli.Fluid shear stress and melatonin in combination activate anabolic proteins in MC3T3-E1 osteoblast cells.MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation.p38-MAPK signaling pathway is not involved in osteogenic differentiation during early response of mesenchymal stem cells to continuous mechanical strain.Fluid shear stress induces osteoblast differentiation and arrests the cell cycle at the G0 phase via the ERK1/2 pathway.Activation of estrogen response elements is mediated both via estrogen and muscle contractions in rat skeletal muscle myotubes.Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces iCombined Fluid Shear Stress and Melatonin Enhances the ERK/Akt/mTOR Signal in Cilia-Less MC3T3-E1 Preosteoblast Cells
P2860
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P2860
Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Mechanical strain and fluid mo ...... different signaling pathways.
@en
type
label
Mechanical strain and fluid mo ...... different signaling pathways.
@en
prefLabel
Mechanical strain and fluid mo ...... different signaling pathways.
@en
P2093
P1433
P1476
Mechanical strain and fluid mo ...... different signaling pathways.
@en
P2093
Pitsillides AA
Rawlinson SC
P304
P356
10.1016/S8756-3282(02)00797-4
P577
2002-07-01T00:00:00Z