Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).
about
Gap junctional regulation of signal transduction in bone cellsOsteocytes: master orchestrators of boneThe Periosteal Bone Surface is Less Mechano-Responsive than the Endocortical.Physiological mechanisms and therapeutic potential of bone mechanosensing.Interaction of connexin43 and protein kinase C-delta during FGF2 signalingOsteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodelingRhoA GTPase interacts with beta-catenin signaling in clinorotated osteoblastsFunctional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones.N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone.Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria.Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient miceType XII collagen regulates osteoblast polarity and communication during bone formationInhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient mice.Connexin 43 channels are essential for normal bone structure and osteocyte viabilityUp-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures.Cx43 and mechanotransduction in bone.Regulation of cellular function by connexin hemichannels.Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice.Muscle-bone interactions during fracture healing.Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodelingConnexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysisERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts.CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN.Role of connexins and pannexins during ontogeny, regeneration, and pathologies of boneBisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice.Gap junctions and hemichannels in signal transmission, function and development of boneBeyond gap junctions: Connexin43 and bone cell signalingConnexins in the skeletonCell-cell communication in the osteoblast/osteocyte lineage.Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healingThe regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascadeAbsence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in miceGap Junctions and Biophysical Regulation of Bone CellsConnexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading.Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process.The osteocyte: an endocrine cell ... and more.
P2860
Q26824408-6B93E709-CDE7-43B2-A6DE-D7DEEA8C2C14Q27022407-F35CFC70-846D-4EAF-8C66-8FEB4778C0B5Q27329010-56FFC036-82D4-4C04-84FA-9678BB43A391Q28082204-952099A3-7DFA-4925-812D-B88B8032AEF6Q28506823-65BE5601-E13E-444D-AD2D-0B36F4FF4703Q28592164-A19FF830-C202-4633-97B0-7AEB44ED6192Q33647689-7F1BB019-5C26-49DD-953E-DBA69CBD2607Q33672577-AB262311-CFBB-4D34-ACCF-D53FA202DACFQ34011665-B03947DD-B723-4785-A1C6-693BFBB592C9Q34012735-95C5FC1C-C457-4C32-A1D2-D5ABD5FCEFB7Q34304843-996786B7-18C9-482D-9202-DD662401A559Q34412279-21732C82-886B-4028-B282-CE3BD436B681Q35047456-E80725F9-5D3A-4DD7-A63F-37923889B1D3Q35049558-0B125413-2EE3-44B1-A092-BBEF1404B798Q35096932-556DD712-288A-440E-A5E0-EA01C4C54C8AQ35125177-D6C49464-3F16-4E88-BAFE-233D0BAEE4CCQ35163731-F54792C5-DB74-4E44-B580-7A5C9098C008Q35232370-E94C982F-5F6E-4CF2-B4AF-97A4CE04C0A7Q35559060-6E64E1D2-E496-42F3-B7F6-228920D54363Q35612050-82594F22-09A4-4B5E-8DA4-C08281003DE0Q35635751-11E0FCA7-38A2-46BA-8684-23465DC25C16Q35647693-73569086-D211-487B-8086-DB0E4FBB27D6Q35729489-5CE10FA0-495D-40C8-9576-7A94835AC122Q35781909-53BFB0DC-51D2-455A-9276-5B43605E3799Q35835319-1F84BF17-6395-4A7A-B517-F5B40DCADBB1Q35900708-BAEB6D38-8BDE-4821-A531-A9DB2F50B5B0Q36008760-959F0DA0-8FEE-4FBA-994F-8DB573E3B4A1Q36031679-2F6FB495-0F37-4AB1-980F-79C5AD008C65Q36205222-F5078E1F-F32F-471D-95A0-3B275F6BFB4EQ36231023-ECECC0A8-4433-491F-9F09-A21CDF8E893FQ36442344-A060531E-BC4E-43D9-85BB-0410EAEA41F4Q36654813-A67AA4B7-F1A6-4CD8-80B1-1BC1CDCB5E48Q36740282-AA27C0EE-74A5-4400-B79D-644A295D33DDQ36807175-B52981FF-B4FE-4BA0-9CDC-E02F8B45D4C5Q36853305-27B93E63-BE05-46B1-BEF7-E7CD7A11EEF5Q36874711-ED644CB8-E55D-4B9B-8D7B-3ED1072F7996Q36916597-8D334E11-23E4-4625-B537-B65EA074C3A6Q36931466-92B6933F-F983-40A6-844F-1F0F3076AC68Q37031872-E71225E4-3584-40DD-B0E7-FBC1F55AE2D2Q37203605-45E9B0A7-F863-4374-B6AD-64122C1E39A8
P2860
Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Attenuated response to in vivo ...... of the connexin43 gene (Gja1).
@en
Attenuated response to in vivo ...... blation of the connexin43 gene
@nl
type
label
Attenuated response to in vivo ...... of the connexin43 gene (Gja1).
@en
Attenuated response to in vivo ...... blation of the connexin43 gene
@nl
prefLabel
Attenuated response to in vivo ...... of the connexin43 gene (Gja1).
@en
Attenuated response to in vivo ...... blation of the connexin43 gene
@nl
P2093
P2860
P356
P1476
Attenuated response to in vivo ...... of the connexin43 gene (Gja1)
@en
P2093
Matthew J Silva
Michael D Brodt
Susan K Grimston
P2860
P304
P356
10.1359/JBMR.080222
P577
2008-06-01T00:00:00Z