ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationThe docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathwaySixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasiasFuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cellsGenomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteinsTrihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migrationThe HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor speciesSimultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia.Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.PfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata.MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral toleranceGastrointestinal growth factors and hormones have divergent effects on Akt activation.Biphasic regulation of ENaC by TGF-{alpha} and EGF in renal epithelial cells.miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer.Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.Network quantification of EGFR signaling unveils potential for targeted combination therapy.Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.Consequences of feedback in signal transduction for targeted therapies.The renewed battle against RAS-mutant cancers.Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancerThe comparison between dual inhibition of mTOR with MAPK and PI3K signaling pathways in KRAS mutant NSCLC cell lines.Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor-kappa B (RANK) Signaling.Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling.Therapeutic strategies for targeting ras proteins.MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors.Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions.Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling.A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.Retinoblastoma protein (Rb) links hypoxia to altered mechanical properties in cancer cells as measured by an optical tweezer.Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown
P2860
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P2860
ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
ERK negatively regulates the e ...... phosphatidylinositol 3-kinase.
@en
type
label
ERK negatively regulates the e ...... phosphatidylinositol 3-kinase.
@en
prefLabel
ERK negatively regulates the e ...... phosphatidylinositol 3-kinase.
@en
P2093
P2860
P356
P1476
ERK negatively regulates the e ...... phosphatidylinositol 3-kinase.
@en
P2093
Cheng Fang Yu
Lloyd G Cantley
Zhen-Xiang Liu
P2860
P304
19382-19388
P356
10.1074/JBC.M200732200
P407
P577
2002-03-14T00:00:00Z