Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.
about
Dynamics of in silico leukocyte rolling, activation, and adhesion.Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragmentGlycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migrationComputational modeling of interactions between multiple myeloma and the bone microenvironmentThe interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRETA Pan-GTPase Inhibitor as a Molecular ProbeActivated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.Allosteric modulation of beta1 integrin function induces lung tissue repairCXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening.Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion.Human eosinophil adhesion and degranulation stimulated with eotaxin and RANTES in vitro: lack of interaction with nitric oxide.Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists.Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion.FRET detection of cellular alpha4-integrin conformational activation.Relationship between molecular and cellular dissociation rates for VLA-4/VCAM-1 interaction in the absence of shear stressBeta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.FRET detection of lymphocyte function-associated antigen-1 conformational extension.Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease.Conformational mAb as a tool for integrin ligand discoveryShort form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit.Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization.Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensionsRoles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma.Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin.A virtual approach to evaluate therapies for management of multiple myeloma induced bone diseaseActive site formation, not bond kinetics, limits adhesion rate between human neutrophils and immobilized vascular cell adhesion molecule 1.SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice.Overview: assays for studying integrin-dependent cell adhesion.Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication of β1-Integrin Activation.Conformational equilibria and intrinsic affinities define integrin activation.Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation.
P2860
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P2860
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Real time analysis of the affi ...... Mn(2+) or antibody activation.
@en
type
label
Real time analysis of the affi ...... Mn(2+) or antibody activation.
@en
prefLabel
Real time analysis of the affi ...... Mn(2+) or antibody activation.
@en
P2093
P2860
P356
P1476
Real time analysis of the affi ...... Mn(2+) or antibody activation.
@en
P2093
Andrews RP
Braaten JV
Edwards BS
Kumaraswamy N
P2860
P304
48670-48678
P356
10.1074/JBC.M103194200
P407
P577
2001-10-18T00:00:00Z