A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.
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A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptorCrystal structure of a lipid G protein-coupled receptorFull pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactionsIntegrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactionsAsymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding ConstraintIdentification of the hydrophobic ligand binding pocket of the S1P1 receptorEndosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signalingCombined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Discovery of new G protein-coupled receptors for lipid mediators.Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1Regulation of immunity by lysosphingolipids and their G protein-coupled receptorsFlow-regulated endothelial S1P receptor-1 signaling sustains vascular developmentDual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivoThe lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.Mitigation of radiation injury by selective stimulation of the LPA(2) receptorVirtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.Lysophospholipid interactions with protein targets.Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta.Palmitoylated cysteine 192 is required for RhoB tumor-suppressive and apoptotic activities.LPA1 is a key mediator of intracellular signalling and neuroprotection triggered by tetracyclic antidepressants in hippocampal neurons.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Molecular recognition in the sphingosine 1-phosphate receptor family.Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptorsSphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors.GPCR Conformations: Implications for Rational Drug Design.'Crystal' Clear? Lysophospholipid Receptor Structure Insights and Controversies
P2860
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P2860
A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
A single amino acid determines ...... lipid growth factor receptors.
@en
type
label
A single amino acid determines ...... lipid growth factor receptors.
@en
prefLabel
A single amino acid determines ...... lipid growth factor receptors.
@en
P2093
P2860
P356
P1476
A single amino acid determines ...... lipid growth factor receptors.
@en
P2093
P2860
P304
49213-49220
P356
10.1074/JBC.M107301200
P407
P577
2001-10-16T00:00:00Z