Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis. - Wikidata - wikimedia - TriplyDB

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

http://www.wikidata.org/entity/Q40781162

about

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice Secretory granule membrane protein recycles through multivesicular bodies Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains.Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse.Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.Autophagy in Alzheimer's disease.Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Very-long-chain fatty acids activate lysosomal hydrolases in neonatal human skin tissue.Up-regulation of glycohydrolases in Alzheimer's Disease fibroblasts correlates with Ras activation.Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase.Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease.

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P2860

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

http://www.wikidata.org/entity/Q40781162

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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Alzheimer's disease-related ov ...... ution in beta-amyloidogenesis.

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Alzheimer's disease-related ov ...... ution in beta-amyloidogenesis.

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Alzheimer's disease-related ov ...... ution in beta-amyloidogenesis.

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Journal of Biological Chemistry

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Alzheimer's disease-related ov ...... ution in beta-amyloidogenesis.

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P2093

Anne M Cataldo

http://www.w3.org/2001/XMLSchema#string

Annette Hille-Rehfeld

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Benjamin H Kao

http://www.w3.org/2001/XMLSchema#string

Carolyn B Guerra

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Jack Rohrer

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Marc Mercken

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Olivera M Grbovic

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Pankaj Mehta

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Paul M Mathews

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Ralph A Nixon

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif

Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus

Neuropathological stageing of Alzheimer-related changes

Non-replication of association between cathepsin D genotype and late onset Alzheimer disease

Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.

Identification of beta-secretase-like activity using a mass spectrometry-based assay system.

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5299-5307

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10.1074/JBC.M108161200

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Alzheimer's disease