Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. - Wikidata - wikimedia - TriplyDB

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

http://www.wikidata.org/entity/Q33667620

about

Dissecting Alzheimer disease in Down syndrome using mouse models The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome Cellular mechanisms of γ-secretase substrate selection, processing and toxicity A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration Rab GTPases, membrane trafficking and diseases Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes Axonal transport and neurodegenerative disease: can we see the elephant?Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patients Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway.The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein.Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Excess betaCTF, not Abeta: the culprit in Alzheimer-related endocytic dysfunction.Pharmacological chaperones stabilize retromer to limit APP processing.Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion.Age and gene overexpression interact to abolish nesting behavior in Tg2576 amyloid precursor protein (APP) mice Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach.Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD).Autophagy failure in Alzheimer's disease--locating the primary defect.A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.Early hyperactivity in lateral entorhinal cortex is associated with elevated levels of AβPP metabolites in the Tg2576 mouse model of Alzheimer's disease.Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation Differential regulation of catechol-O-methyltransferase expression in a mouse model of aggression.Nanoparticle-mediated signaling endosome localization regulates growth cone motility and neurite growth.Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis Age-related neurodegeneration and memory loss in down syndrome.BACE2 expression increases in human neurodegenerative disease.Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.

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P2860

Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.

http://www.wikidata.org/entity/Q33667620

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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type

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition.

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PNAS.0908953107

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Proceedings of the National Academy of Sciences of the United States of America

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Alzheimer's-related endosome d ...... reversed by BACE-1 inhibition

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Anne Boyer-Boiteau

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Anne M Cataldo

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Corrinne M Peterhoff

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Kerry A Mullaney

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Ralph A Nixon

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Shaoli Che

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Stephen D Schmidt

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Ying Jiang

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

A system for stable expression of short interfering RNAs in mammalian cells

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting.

Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

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1630-1635

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4

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107

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Stephen D Ginsberg

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41040208

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20080541

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Alzheimer's disease

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2824382

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