Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
about
The p53 family member genes are involved in the Notch signal pathwayConserved signal peptide of Notch3 inhibits interaction with proteasomeDual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signalingAntibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivoIdentification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeatsMutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotypePapillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activationEvolution of distinct EGF domains with specific functionsThrombospondin 2 potentiates notch3/jagged1 signalingTranscriptional oscillation of lunatic fringe is essential for somitogenesisProtein O-fucosyltransferase 1 is an essential component of Notch signaling pathwaysImpact of notch signaling on inflammatory responses in cardiovascular disordersFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsMolecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notchManic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulationNotch ligands are substrates for protein O-fucosyltransferase-1 and FringeFunctional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cellsRTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiationBiochemical characterization and cellular effects of CADASIL mutants of NOTCH3Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentThe Mesp2 transcription factor establishes segmental borders by suppressing Notch activityContext-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In VivoRegulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase RumiThe extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney developmentFringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasiaSegmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceO-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand functionO-fucosylation of DLL3 is required for its function during somitogenesisThe divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligandsFunctional diversity of notch family genes in fetal lung developmentThe canonical Notch signaling pathway: unfolding the activation mechanism.Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.Glycans - the third revolution in evolution.Ubiquitous Importance of Protein Glycosylation.Competition between Delta and the Abruptex domain of NotchNotch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisitionTurn It Down a NotchEffects of varying Notch1 signal strength on embryogenesis and vasculogenesis in compound mutant heterozygotes.
P2860
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P2860
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
@en
type
label
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
@en
prefLabel
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
@en
P2093
P356
P1433
P1476
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.
@en
P2093
P2888
P304
P356
10.1038/35019553
P577
2000-08-01T00:00:00Z