DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.
about
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Overcoming cisplatin resistance by mTOR inhibitor in lung cancer.mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsThe Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual DysfunctionTarget of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavagesThe tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesInternal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stressAntitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrolCaspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motifATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROSBiomarker Development for the Clinical Activity of the mTOR Inhibitor Everolimus (RAD001): Processes, Limitations, and Further ProposalsTranslational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.DNA damage and autophagy.Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway.Cellular senescence in cancer treatment: friend or foe?Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(II) complexes.Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.Initiation factor modifications in the preapoptotic phase.PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathwaysStress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB)Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatmentRegulation of protein synthesis by ionizing radiation.p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.Translation initiation: a critical signalling node in cancer.The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin.Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signalingBeyond ATM: the protein kinase landscape of the DNA damage response.Anti-oncogenic potential of the eIF4E-binding proteins.At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence.Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.Signaling Pathways and Emerging Therapies in Multiple Myeloma.Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1-Bad-Bak pathway in peritoneal carcinomatosis
P2860
Q24316314-FBB90D9D-8B0A-43DC-849B-E74C24B111FDQ24519078-22080326-2C52-42DB-A35B-D5ADCF3931F8Q24815638-321F110E-57EC-4CBB-97D2-844B340A7008Q27007511-90A4AC15-4924-40A8-A633-7746F46AB3D8Q27334692-524F47D6-AAC1-4F4E-BD59-A8EC9CAE13C3Q28200932-354B4D6E-4260-41D9-B7E6-778888B4DEC7Q28207255-669F9CF9-6714-4BD4-9CB4-4D7BE005A797Q28240102-CA384267-EC0B-46D2-BFA3-075EA47007E9Q28355608-01CA0DFC-4E00-47D4-A3EF-6BA99B6F276FQ28475419-D3EB92B3-497D-433E-AFA2-F9F8EC2600ECQ28579562-69C744EA-1682-4C7C-A19D-D95830EEA857Q33733064-2E135600-56EA-42C9-9A23-DDA036A4DE84Q33760578-AEEBC710-DB87-45CA-9F5E-859829A73423Q34277370-B407836C-E511-4A60-879D-68213A01C465Q34381683-FA8341B6-9B33-4333-9F19-022E3CB2409EQ34524094-4FAA8A35-BB12-49FA-9BA5-8F4EA27EFBD0Q35017721-C07C6D6C-ADD1-4525-8626-7FC903D183C9Q35024843-080FF593-59D6-408A-83E3-0F5F818FE648Q35628579-72E82E33-ACE8-4CC5-A8C7-093B8735E0B0Q35751948-43A5E202-BAD4-44AC-9E2A-AB6827B7434EQ35829015-4D6CC696-09E6-4375-9140-EBB7A9EF07E9Q36099275-F917FEAC-E0F7-49F6-B6E6-5296B78A88E4Q36131043-8AFC02B0-FEE3-4D52-AF35-E2365804111AQ36878777-9B17F1E1-089D-4589-9AC4-A39077596B14Q36940460-F60A526A-8554-4705-A888-A259B729ABDAQ36941654-31548960-1906-4B83-9129-B9421F0D642BQ36997524-40312652-3357-4102-A1BE-CE0DD4744C65Q37410747-CFDE8B3F-2E12-48E6-A08B-E6BC2C1EF897Q37583480-6EA55DEF-BAEB-4D07-8713-DC509AA895D6Q37586472-0DA304A0-D841-4025-9BBF-15B271F1DB48Q37603650-D2ADF097-96D6-4A58-8317-D07CB0EA9E40Q37618598-5AAFD862-505C-413B-9AFD-E085247E2D8BQ37780207-3E6AB186-6560-4215-A997-6606B12640A0Q37875377-73FCF88D-63F0-4DF7-A2A8-3BB3B86B7AB6Q38003091-7F46B3A9-291C-4DCC-87C8-80B56CA79300Q38130677-8AE96C18-C5DD-4529-88F8-2CF6E74F8DCAQ38715697-6F6D0C56-7446-4917-8E12-0EC7FD991B93Q38753307-49F4F8B8-E6BF-4797-AD68-F5751105A35CQ38783139-3ACDF5AF-24A0-4FE9-82A2-9AA15A844E79Q38988038-DF4C1A12-0D41-4C34-80E8-0C62B7388991
P2860
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
DNA-damaging agents cause inac ...... ors linked to mTOR signalling.
@en
type
label
DNA-damaging agents cause inac ...... ors linked to mTOR signalling.
@en
prefLabel
DNA-damaging agents cause inac ...... ors linked to mTOR signalling.
@en
P2860
P356
P1433
P1476
DNA-damaging agents cause inac ...... ors linked to mTOR signalling.
@en
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203622
P407
P577
2000-06-01T00:00:00Z
P5875
P6179
1010989642