Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
about
Explaining oscillations and variability in the p53-Mdm2 systemHDACs and the senescent phenotype of WI-38 cells.It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer DiseaseMitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?Proteostasis and longevity: when does aging really begin?Transgenic animal models for study of the pathogenesis of Huntington's disease and therapyProtein Oxidation in Aging: Does It Play a Role in Aging Progression?Heat shock proteins in neurodegenerative disorders and agingPlasticity at glycinergic synapses in dorsal cochlear nucleus of rats with behavioral evidence of tinnitus.Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleusCatalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal.Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.Role of proteasomes in disease.Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.Persistent hijacking of brain proteasomes in HIV-associated dementia.Remodeling of Proteostasis Upon Transition to Adulthood is Linked to Reproduction Onset.Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.Protein homeostasis and aging: The importance of exquisite quality control.Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanismLate-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Amyotrophic lateral sclerosis: a proposed mechanism.NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.Failure of the ubiquitin-proteasome system in Parkinson's disease.Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.The biology of proteostasis in aging and disease.Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.Ischemic tolerance in an in vivo model of glutamate preconditioning.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Increased protein hydrophobicity in response to aging and Alzheimer diseaseGlobal transcriptional profiling using RNA sequencing and DNA methylation patterns in highly enriched mesenchymal cells from young versus elderly women.Changes in 20S subunit composition are largely responsible for altered proteasomal activities in experimental autoimmune encephalomyelitis.Disruption of protein quality control in Parkinson's disease.Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress.Myelin pathogenesis and functional deficits following SCI are age-associated.Aging and regulated protein degradation: who has the UPPer hand?The ubiquitin-proteasome system in Huntington's disease.Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.Essential role of proteasomes in maintaining self-renewal in neural progenitor cells.Maintenance of proteins and aging: the role of oxidized protein repair.
P2860
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P2860
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
@en
type
label
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
@en
prefLabel
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
@en
P2093
P1433
P1476
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
@en
P2093
J N Keller
W R Markesbery
P304
P356
10.1016/S0306-4522(00)00067-1
P407
P577
2000-01-01T00:00:00Z