Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.
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Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicitySynthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulinIs the neutrophil a 'prima donna' in the procoagulant process during sepsis?Regulation of thrombosis and vascular function by protein methionine oxidationCrossroads of coagulation and innate immunity: the case of deep vein thrombosisDeficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosisStructural basis for the anticoagulant activity of the thrombin-thrombomodulin complexMolecular basis of thrombomodulin activation of slow thrombinStructure-function relationship in an archaebacterial methionine sulphoxide reductase BThe structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulinThe interaction of thrombomodulin with Ca2+TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complexFolate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient miceMurine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosisATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation.Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13.Peptide methionine sulfoxide reductase: biochemistry and physiological role.The Williams-Beuren Syndrome-a window into genetic variants leading to the development of cardiovascular disease.Protein C replacement in severe meningococcemia: rationale and clinical experience.Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy.Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine lifeNew mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins.Protein C pathway in sepsis.Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation.Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathwaysFibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen.In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A.Effects of anticoagulant strategies on activation of inflammation and coagulation.Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury.Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model.Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo.The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern.Modulating protein activity and cellular function by methionine residue oxidation.Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects.New insights into modulation of thrombin formation.Gene expression profiling of the early pulmonary response to hyperoxia in mice.Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor
P2860
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P2860
Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Oxidation of a specific methio ...... for modulation of coagulation.
@en
type
label
Oxidation of a specific methio ...... for modulation of coagulation.
@en
prefLabel
Oxidation of a specific methio ...... for modulation of coagulation.
@en
P2093
P2860
P356
P1476
Oxidation of a specific methio ...... for modulation of coagulation.
@en
P2093
C B Glaser
J H Clarke
L Vilander
P2860
P304
P356
10.1172/JCI116151
P407
P577
1992-12-01T00:00:00Z