Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor.
about
The antipsychotic potential of muscarinic allosteric modulationChemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's DiseaseAllosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryMalignant synaptic growth and Alzheimer's disease.Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine coreOptimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeNovel heteroaryl phosphonicdiamides PTPs inhibitors as anti-hyperglycemic agents.Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
P2860
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P2860
Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Synthesis and structure-activi ...... arinic acetylcholine receptor.
@en
type
label
Synthesis and structure-activi ...... arinic acetylcholine receptor.
@en
prefLabel
Synthesis and structure-activi ...... arinic acetylcholine receptor.
@en
P2093
P2860
P356
P1433
P1476
Synthesis and structure-activi ...... arinic acetylcholine receptor.
@en
P2093
Alexander S Kane
Ashley E Brady
Carrie K Jones
J Phillip Kennedy
Jana K Shirey
John T Brogan
Patrick R Gentry
Thomas M Bridges
P2860
P304
P356
10.1002/CMDC.200900231
P577
2009-10-01T00:00:00Z