Altered T cell receptor ligands trigger a subset of early T cell signals.
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Quantitative challenges in understanding ligand discrimination by alphabeta T cellsModeling T cell antigen discrimination based on feedback control of digital ERK responsesTCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of DifferentiationTo affinity and beyond: harnessing the T cell receptor for cancer immunotherapyEarly T cell signalling is reversibly altered in PD-1+ T lymphocytes infiltrating human tumorsStructural Basis of Cytochrome c Presentation by IE kIn vitro evolution of a T cell receptor with high affinity for peptide/MHC.A role for rebinding in rapid and reliable T cell responses to antigenThe SCHOOL of nature: I. Transmembrane signaling.Variant antigenic peptide promotes cytotoxic T lymphocyte adhesion to target cells without cytotoxicityAttenuated T cell responses to a high-potency ligand in vivo.The impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Perspectives for computer modeling in the study of T cell activationTCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation.Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity.A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 DimerizationMechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition.T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation.Allelic variation of MHC structure alters peptide ligands to induce atypical partial agonistic CD8+ T cell function.The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands.Kinetics and extent of T cell activation as measured with the calcium signalAnalysis of the expression of peptide-major histocompatibility complexes using high affinity soluble divalent T cell receptorsDissociation of intracellular signaling pathways in response to partial agonist ligands of the T cell receptor.Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells.A logical analysis of T cell activation and anergy.Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complexHomeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands.Functional evidence for TCR-intrinsic specificity for MHCII.Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosisT-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity.Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels.Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation.Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy.The functional contribution of calcium ion flux heterogeneity in T cells.Substitutions in a major histocompatibility complex class II-restricted human immunodeficiency virus type 1 gp120 epitope can affect CD4+ T-helper-cell function.Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.
P2860
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P2860
Altered T cell receptor ligands trigger a subset of early T cell signals.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Altered T cell receptor ligands trigger a subset of early T cell signals.
@en
type
label
Altered T cell receptor ligands trigger a subset of early T cell signals.
@en
prefLabel
Altered T cell receptor ligands trigger a subset of early T cell signals.
@en
P2093
P1433
P1476
Altered T cell receptor ligands trigger a subset of early T cell signals.
@en
P2093
McConnell HM
Rabinowitz JD
P304
P356
10.1016/S1074-7613(00)80489-6
P407
P577
1996-08-01T00:00:00Z