The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines.
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Temperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA virusesAttenuating mutations of the matrix gene of influenza A/WSN/33 virus.Human trials with wild-type H1N1 and recombinant H3N2-H1N1 influenza A viruses of 1977-1978.Effect of cell-mediated immune factors on the replication of an attenuated temperature-sensitive mutant of vaccinia virusLive-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics.The temperature-sensitive (ts) phenotype of a cold-passaged (cp) live attenuated respiratory syncytial virus vaccine candidate, designated cpts530, results from a single amino acid substitution in the L protein.Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes.Evaluation of a phenotypic revertant of the A/Alaska/77-ts-1A2 reassortant virus in hamsters and in seronegative adult volunteers: further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-1A2 reassortant virusesCharacterization of the temperature sensitive phenotype of the A/Ann Arbor/6/60 cold-adapted virus and its recombinantsSelection of cold-adapted mutants of human rotaviruses that exhibit various degrees of growth restriction in vitro.Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines.Reovirus serotype 1 intestinal infection: a novel replicative cycle with ileal disease.In vitro and in vivo properties of chemically induced temperature-sensitive mutants of Chlamydia psittaci var. ovis: screening in a murine modelUse of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.An influenza A virus containing influenza B virus 5' and 3' noncoding regions on the neuraminidase gene is attenuated in mice.Biochemical characterizations of two temperature-sensitive and attenuated strains of respiratory syncytial virus subgroup B.NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.
P2860
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P2860
The association of the temperature-sensitive phenotype with viral attenuation in animals and humans: implications for the development and use of live virus vaccines.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年論文
@yue
1979年論文
@zh-hant
1979年論文
@zh-hk
1979年論文
@zh-mo
1979年論文
@zh-tw
1979年论文
@wuu
1979年论文
@zh
1979年论文
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name
The association of the tempera ...... nd use of live virus vaccines.
@en
type
label
The association of the tempera ...... nd use of live virus vaccines.
@en
prefLabel
The association of the tempera ...... nd use of live virus vaccines.
@en
P1476
The association of the tempera ...... nd use of live virus vaccines.
@en
P2093
P304
P577
1979-05-01T00:00:00Z